Human ribonucleotide reductase (hRR) is the key enzyme involved in de novo dNTP synthesis and thus represents an important therapeutic target against hyperproliferative diseases, most notably cancer. The purpose of this study was to evaluate the ability of non-natural indolyl-2'-deoxynucleoside triphosphates to inhibit the activity of hRR. The structural similarities of these analogues with dAT...

In the title compound, C(13)H(10)OS(2), the dihedral angle between the thio-phene rings is 14.3 (1)°. The mol-ecular structure is stabilized by C-H⋯π inter-actions between a thio-phene H atom and an adjacent thio-phene ring, and by inter-molecular C-H⋯O hydrogen bonds.

The asymmetric unit of the title compound, C(19)H(16)O(2)S(2), contains two independent mol-ecules with slightly different conformations. In the crystal structure, weak inter-molecular C-H⋯O hydrogen bonds [C⋯O = 3.279 (15) and 3.407 (16) Å] link the mol-ecules into chains extended along the c axis.

The title compound, C(19)H(17)N(3)O, was prepared by the 1,4-addition reaction of 1,3-di-2-pyridylprop-2-en-1-one with aniline, and includes one chiral C atom of the methine group with an R configuration. The crystal structure is stabilized by inter-molecular N-H⋯N and C-H⋯O hydrogen bonds. The crystal structure also exhibits weak inter-molecular C-H⋯π inter-actions between a pyridyl H atom and...

In the title compound, C(25)H(23)N, the indole unit makes a dihedral angles of 79.03 (5) and 61.82 (4)° with the benzene rings. No classical hydrogen bonds are found in the crystal structure.

In the title 2-propanol derivative, C(17)H(27)ClO(2), the two tert-butyl groups both have one methyl C atom lying in the plane of the aromatic ring. In the crystal, the phenol group forms a hydrogen bond to the hy-droxy O atom belonging to the alkyl substituent of an adjacent mol-ecule, forming a chain along the ac diagonal. The Cl atom is disordered over two positions in a 0.73 (4):0.27 (4) ra...

The characteristics of the Ca(2+) entry pathways that are activated by protein kinase C (PKC) in canine splenic artery were investigated. Phorbol 12, 13-dibutyrate (PDB) contracted tissues and increased Ca(2+) influx. PDB-induced contraction was reduced by preincubation of tissues in Ca(2+)-free Krebs' solution (1 mM EGTA) but was unaffected when Ca(2+)-free solution was applied after contracti...

A novel mechanistic duality has been revealed from the indolyl 1,3-heteroatom transposition (IHT) of N -hydroxyindole derivatives.