Negative results are reported for five compounds tested against mouse Sarcoma 180. Twelve mice, 18 gm. Rockland and Carworth Farms mice, were used for each test. The tumors were implanted subcutaneously by trocar in the right axilla. When the implants were seven days old the compounds were in jected intraperitoneallytwice a day for seven days. The compounds were tested at the maximum non-lethal...

BACKGROUND Our objective was to assess time to achieve blood-pressure (BP) goal with incremental doses of valsartan alone, and together with hydrochlorothiazide (HCTZ), in patients with uncomplicated hypertension. METHODS This analysis pooled patient-level data from nine randomized, double-blind, fixed-dose, placebo-controlled trials (N = 4278) of once-daily valsartan 80 mg, 160 mg, and 320 m...

Environmental pollution with heavy metals is a global disaster that is related tohuman activities. This study was conducted to determine the extent of heavy metalsaccumulation by plant species in Lia industrial city (Qazvin, Iran) and to investigate theremediative capacity of native plant species grown in the contaminated soils. Soil andindustrial wastewater sampling was done radially along tra...

The effects of dietary-induced acidosis on the growth and rates of complete regression of Sarcoma 180 in mice have been studied. The experiments here reported have demonstrated that mineral acidification of laboratory food produces a late decrease in tumor growth and significantly increases the rates of complete tumor regression. Blood acid-base studies also demonstrate the effects of these die...

The growth rate of Sarcoma 180 and of a mammary adenocarcinoma in potassium deficient mice did not significantly differ from that in pair-fed control mice. The po tassium concentration of these tumors in potassium-deficient mice was the same as in the control mice, although the potassium concentration of muscle and plasma was only half of that in the controls. The in vivo equilibration of K@ in...

OBJECTIVE Determine the effect of a matrix metalloproteinase inhibitor (MMPi) and angiotensin converting enzyme inhibitor (ACEi) on collagen, MMP, tissue inhibitors of MMPs (TIMPs) expression in the spontaneously hypertensive heart failure (SHHF) rat. METHODS Six groups were tested: normotensive 9- and 13-month-old Wistar-Furth (WF) rats, 9-month-old SHHFs (compensatory hypertrophy), 13-month...