The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral. The IL-17R signaling and downstream pathways mediate induction of proinflammatory molecules which participate in control of these pathogens. However, the production of IL-17 can also mediate pa...

GPP is a rare potentially life-threatening disease characterized by the presence of sterile pustules on erythematous skin. Although clinically different from psoriasis vulgaris (PV) it shares some features PV such as spongiform pustule. The cause unknown; triggers include infections, corticosteroid withdrawal and genetic factors mutation IL-36 RN antagonizing IL36-G -A. Antibody treatment with ...

T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of interleukin-17A (IL-17A), IL-17F, IL-21, and IL-22. Th17 cells and their effector cytokines mediate host defensive mechanisms to various infections, especially extracellular bacteria infections, and are involved ...