In this article we infer the rates of gene conversion and crossing over in Arabidopsis thaliana from population genetic data. Our data set is a genomewide survey consisting of 1347 fragments of length 600 bp sequenced in 96 accessions. It has several orders of magnitude more markers than any previous nonhuman study. This allows for more accurate inference as well as a detailed comparison betwee...

Synaptic hypothesis of schizophrenia suggests that alterations of synaptic transmission and neuronal connectivity might be core feature of schizophrenia. STON2 participates in synaptic vesicle protein recognition and neural endocytosis. To explore the association of STON2 with schizophrenia, 11 single nucleotide polymorphisms (SNPs) were examined in 768 Chinese Han schizophrenia cases and 1347 ...

Tafti, Mehdi, and Paul Franken. Invited Review: Genetic dissection of sleep. J Appl Physiol 92: 1339–1347, 2002; 10.1152/japplphysiol. 00834.2001.—Recent advances in genomics open up new avenues in the analysis of complex behaviors such as sleep. In this analysis, the mouse is the model species of choice because it is amenable to high throughput phenotype and genotype analysis. With the use of ...

We estimated the potential impact of parental Tdap immunization before delivery, at delivery and at the 2-week newborn visit on U.S. infant pertussis hospitalizations. We used published data for pertussis hospitalization rates among U.S. infants aged 0-4 months, the Tdap vaccine efficacy in adults, and the proportion of infants with pertussis <6 months of age in which either parent was the sour...

BACKGROUND Due to high prevalence of oral diseases extraction of primary teeth is a common and a major concern in developing countries. These teeth are given least importance as they are believed to shed off automatically, thus leading to serious problems like crowding and malocclusion. MATERIAL AND METHODS A cross sectional study was carried out among children aged 5 to 12 years among 1347 c...

tion after low molecular weight dextran infusion in sheep. Med J Austr 18: 539-541, 1967 31. Cox EF, Flotte CT, Buxton RW: Dextran in the treatment of thrombophlebitis. Surgery 57: 225-229, 1965 32. Weiss HJ: Antiplatelet therapy. N Eng J Med 298: 1344-1347, 1978 33. Bygdeman S: Experimental studies on the antithrombotic effect of dextran. Acta Chir Scand 387: (Suppl) 44-52, 1968 34. Boschenste...

Growth of transition metal dichalcogenide (TMD) monolayers is of interest due to their unique electrical and optical properties. Films in the 2H and 1T phases have been widely studied but monolayers of some 1T'-TMDs are predicted to be large-gap quantum spin Hall insulators, suitable for innovative transistor structures that can be switched via a topological phase transition rather than convent...

One of the fastest growing areas of scienti c computing is in the nancial industry. Many of the most basic problems in nancial analysis are still unsolved, and are surprisingly resilient to the onslaught of legions of talented researchers from many diverse disciplines. In this article, we hope to give readers a sense of these challenges by describing a relatively simple problem that all investo...