Morphine, which is agonist for μ-opioid receptors, has been used as an anti-pain drug for millennia. The opiate antagonists, naloxone and naltrexone, derived from morphine, were employed for drug addiction and alcohol abuse. However, these exogenous agonists and antagonists exhibit numerous and unacceptable side effects. Of the endogenous opioid peptides, endomorphin(EM)-1 and endomorphin(EM)-2...

Available serological diagnostics do not allow the confirmation of clinically suspected leptospirosis at the early acute phase of illness. Several conventional and real-time PCRs for the early diagnosis of leptospirosis have been described but these have been incompletely evaluated. We developed a SYBR Green-based real-time PCR targeting secY and validated it according to international guidelin...

Whole genome sequencing (WGS) has helped to revolutionize biology, but the computational challenge remains for extracting valuable inferences from this information. Here, we present cancer-associated variants Cancer Genome Atlas (TCGA) WGS dataset. This set of data will allow cancer researchers further expand their analysis beyond exomic regions entire genome. A total 1342 alignments available ...

A surface alloying technique is developed to enrich the internal surfaces of low‐carbon steel casting with nickel or and chromium. This unique involves incorporation (Ni), chromium (Ni + Cr), stainless (SS) powders into a slurry, then applying slurry onto cores used in sand molds which comes contact molten metal during casting. Various properties, including coating thickness, composition, micro...

Norşîn dergâhının temsilcilerinden Muhammed Diyâuddîn Norşînî (ö.1342/1924), Bitlis ve çevresinin manevî mimarlarından biri olarak kabul edilir. “Şeyh Hazret” şöhret bulan tedrîs, tebliğ İslam adına yaptığı cihat faaliyetleriyle birlikte, yörenin ictimaî alanında faal rol oynamıştır. Tasavvuf literatüründe mektûbât geleneğinin bir parçası sayılabilecek mektupları; tasavvuf, fıkıh kelam değerlen...

We point out that the electro-optic modulation of bound state in continuum a low-index dielectric-loaded slab L mathvariant="normal">i mathvariant="normal">N mathvariant="normal">b mathvariant="normal">O</mml:mi...