IL-4 is a key cytokine associated with allergy and asthma. Induction of cell signaling by IL-4 involves interaction with its cognate receptors, a complex of IL-4Ralpha with either the common gamma-chain or the IL-13R chain alpha1 (IL-13Ralpha1). We found that IL-4 bound to the extracellular domain of IL-4Ralpha (soluble human (sh)IL-4Ralpha) with high affinity and specificity. In contrast with ...

Mammalian interleukin-13 (IL-13) is an important regulatory T2 cytokine secreted by activated T lymphocytes. The IL-13 receptor (IL-13R) has two different chains, IL-13Ralpha1 and IL-13Ralpha2. Although the chicken IL-13 gene is well characterized, little is known about IL-13Rs. We cloned a cDNA encoding the 380 amino acid pro-peptide of chicken IL-13Ralpha2 (chIL-13Ralpha2) and developed a mon...

This research examines the influence of consumer regulatory focus on preference for product bundles. Product bundling is a type promotion in which multiple products are combined as single comprehensive package, commonly accompanying with price discounts. focuses non-variety bundle that includes units same item and variety composed different vary terms ingredients, taste, or flavor, It hypothesi...

Paramyotonia congenita was first described by Eulenberg (1886). It is a rare, hereditary disorder of muscle in which severe loss of power is induced by degrees of cooling which are insufficient to affect normal muscle. Myotonia also appears on cooling. However, the paralysis produced by cooling distinguishes paramyotonia from Thomsen's disease. The weakness and myotonia can easily be produced u...

Unlike most other agronomic crops, the selection of a bermudagrass cultivar is a long-term commitment. Bermudagrass is a warm-season perennial grass that can persist and withstand the rigors of grazing and hay production for decades. Establishing it, however, is a significant investment that pays off over the long-term. It is important to understand the characteristics of the different cultivar...