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INTRODUCTION Antineoplastic chemotherapy remains one of the most widely used management strategies in cancer, either alone or in combination with other types of treatment. The main inconvenience of chemotherapy is its lack of selectivity, since it acts upon both tumor cells and rapidly multiplying normal cells such as bone marrow cells, hair follicle cells and oral and gastrointestinal mucosal ...
Maydup ML, Antonietta M, Guiamet JJ, Graciano C, Lopez JR, Tambussi EA. 2010. The contribution of ear photosynthesis to grain filling in bread wheat (Triticum aestivum L.). Field Crops Research 119, 48–58. Motzo R, Giunta F. 2002. Awnedness affects grain yield and kernel weight in near-isogenic lines of durum wheat. Australian Journal of Agricultural Research 53, 1285–1293. Rebetzke GJ, Bonnett...
Abstract Reverse fractionation modeling considering energy-constrained assimilation-fractional crystallization is performed to estimate primary magma compositions, degree of crustal contamination, pressure–temperature equilibrium with mantle, and potential temperatures for the origin Paleoproterozoic (~ 2.37–1.88 Ga) basaltic dikes in central eastern Dharwar Craton sills volcanics adjoining Cud...
Alcohol dependence symptoms and consumption measures were examined for stability and heritability. Data were collected from 12,045 individuals (5376 twin pairs, 1293 single twins) aged 19 to 90 years in telephone interviews conducted in three collection phases. Phases 1 and 2 were independent samples, but Phase 3 targeted families of smokers and drinkers from the Phase 1 and 2 samples. The stab...
BACKGROUND The aim of this study was to analyze the benefits and safety associated with the combination therapy of clopidogrel and aspirin among minor stroke or transient ischemic attack patients treated within 12 hours. METHODS AND RESULTS This was a subanalysis of the CHANCE (Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events) trial, mainly limited to the presp...
A variant was selected from a clinical isolate of herpes simplex virus type 1 (HSV-1) during a single passage in the presence of a helicase-primase inhibitor (HPI) at eight times the IC(50). The variant was approximately 40-fold resistant to the HPI BAY 57-1293 and it showed significantly reduced growth in tissue culture with a concomitant reduction in virulence in a murine infection model. The...
KCNK17 (potassium channel, subfamily K, member17) was first discovered to associate with the pathogenesis of ischemic stroke in the first genome-wide association study. The rs10947803 SNP in KCNK17 is significantly associated with ischemic stroke in Caucasian populations. The aim of the present study was to investigate the association with strokes in the Chinese population. A total of 1364 stro...
Objective—Intimal growth depends on smooth muscle cell (SMC) migration and proliferation and is regulated by thrombotic and inflammatory responses to vascular injury. Platelet-derived growth factor (PDGF)-BB and interleukin (IL)-1 have been shown to contribute to intimal hyperplasia and lesion progression in atherosclerosis. Mitogenic effects of IL-1 on SMCs have been reported and have been att...
Human immunodeficiency virus (HIV) type 1 RNA loads were determined for 256 subjects with early (incident) HIV infection and for 1293 subjects with later (prevalent) HIV infection, in a Ugandan cohort. Prevalent infections were classified as latent (0-1 symptoms) and midstage disease (>/=2 symptoms), and deaths were ascribed to acquired immunodeficiency syndrome. Among subjects with incident HI...
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