نتایج جستجو برای: 124
تعداد نتایج: 18504 فیلتر نتایج به سال:
Transforming growth factor-α (TGF-α) is upregulated in advanced stages of prostate cancer and strongly correlated with metastasis. However, the effect of TGF-α on epithelial-mesenchymal transition (EMT) in prostate cancer and the underlying mechanisms remain unclear. Recently, microRNAs have emerged as new regulators of EMT. This study found that treatment of DU145 cells with TGF-α suppressed t...
OBJECTIVE Huntington's disease (HD) is a genetic neurodegenerative disease that is caused by abnormal CAG expansion. Altered microRNA (miRNA) expression also causes abnormal gene regulation in this neurodegenerative disease. The delivery of abnormally downregulated miRNAs might restore normal gene regulation and have a therapeutic effect. METHODS We developed an exosome-based delivery method ...
Administration of the selective adenosine A1 receptor antagonist, CVT-124, to conscious chronically instrumented rats resulted in significant increases in urine flow rate and sodium excretion without affecting potassium excretion or renal hemodynamics. Its maximum effect was twice that of hydrochlorothiazide which was associated with a significant kaliuresis. The diuretic effect of CVT-124 was ...
مطالعات تطبیقی در متون اسلامی، به ویژه در آیات قرآن، از جایگاه ویژه‌ای برخوردار است. با توجه به اهمیت آیه 124 سوره بقره، به دلیل به کار رفتن واژه‌هایی مانند «کلمات»، «امام» و «عهد» که باعث شده برخی مفسران دیدگاه‌های متفاوتی را در این زمینه بیان کنند، پژوهش حاضر به بررسی آراء مفسران فریقین در این زمینه پرداخته است. سه واژۀ «کلمات»، «امام» و «عهد» در آیه پیش‌گفته نقش تعیین‌کننده‌ای برای تبی...
INTRODUCTION Fialuridine (FIAU) is a nucleoside analog that is a substrate for bacterial thymidine kinase (TK). Once phosphorylated by TK, [(124)I]FIAU becomes trapped within bacteria and can be detected with positron emission tomography/computed tomography (PET/CT). [(124)I]FIAU PET/CT has been shown to detect bacteria in patients with musculoskeletal bacterial infections. Accurate diagnosis o...
BACKGROUNDS/AIMS Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA's target genes is reported to play crucial roles in malignancy. In addition, Androgen receptor (AR) is considered to be involved in bladder cancer progression. In this study, we investigated the role of XIST in hu...
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