Meticulous neuroradiological evaluations, including 123I-iomazenil (IMZ) single photon emission computed tomography (SPECT) and 11C-flumazenil (FMZ) positron emission tomography (PET), preoperatively disclosed epileptogenic foci in a 16-year-old boy with temporal lobe epilepsy. Interictal scalp electroencephalography showed spikes in the left temporal region. Left hippocampal sclerosis was seen...

The importance of neuronal dysfunction in the progression of heart failure and the utility of cardiac sympathetic imaging for identifying ischemic cardiomyopathy patients who are at high risk of sudden cardiac death is well established. On the basis of the results of the ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) multicenter trial, 123I-meta-iodobenzylguanidine...

The flagellum of Euglena gracilis has been studied comparatively, using the freeze-fracture technique and with thin sections involving a tannic acid staining procedure. The flagellar membrane exhibits specializations in the form of two groups of intramembrane particle rows (IMP rows; mean IMP diameter, 6 nm) and single clusters of larger IMPs (mean IMP diameter, 10 nm) associated with the edge ...

[(123)I]N-Isopropyl-p-iodoamphetamine hydrochloride ([(123)I]IMP) is clinically used to evaluate blood flow in the brain on single photon emission-computed tomography. This is a rare radiopharmaceutical that undergoes metabolism. The first step is reported to be [(123)I]p-iodoamphetamine formation. The drug-metabolizing enzyme(s) involved remain(s) unclear. This study examined the roles of huma...

Stone AJ, Copp SW, McCord JL, Kaufman MP. Femoral artery ligation increases the responses of thin-fiber muscle afferents to contraction. J Neurophysiol 113: 3961–3966, 2015. First published April 8, 2015; doi:10.1152/jn.00288.2015.—Previous evidence has shown that ligating the femoral artery for 72 h resulted in an exaggerated exercise pressor reflex. To provide electrophysiological evidence fo...

Cnidii Monnieri [Cnidium monnieri (L.) Cusson] is one of the most common used herbal plants in the treatment of numerous ailments including reproductive diseases for hundred of years. Total coumarins of Cnidii Monnieri (TCCM) is a key ingredient. Osthole (Ost) and Imperatorin (Imp) are two main effective ingredients enriched in TCCM. The purpose of this study was to investigate the pharmacokine...

1.1 Technique of nigrostriatal FP-CIT SPECT The density of the presynaptic dopamine reuptake transporters (DAT) can be quantified with [123I]FP-CIT SPECT. The tracer Fluorpropyl-Carbomethoxy-Iodophenyl-Tropan (FPCIT), marked by radioactive 123iodine [123I] (therefore the name [123I]FP-CIT), binds reversibly to the DAT on the presynaptic membrane. Before application of FP-CIT, the iodine uptake ...