Biotechnology and BioengineeringVolume 119, Issue 3 p. 671-675 ISSUE INFORMATIONFree Access Bioengineering: Volume Number 3, March 2022 First published: 07 February https://doi.org/10.1002/bit.27825AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms Conditions of Use check box below share ver...

Biotechnology and BioengineeringVolume 119, Issue 4 p. 1043-1045 ISSUE INFORMATIONFree Access Bioengineering: Volume Number 4, April 2022 First published: 10 March https://doi.org/10.1002/bit.27826AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms Conditions of Use check box below share vers...

The tyrosine kinase, Janus kinase-2 (Jak2), plays a pivotal role in signal transduction through a variety of cytokine receptors, including the receptor for erythropoietin (Epo). Although the physiological relevance of Jak2 has been definitively established, less is known about its regulation. In studies assessing the roles of sites of tyrosine phosphorylation, we identified Y(119) in the FERM (...

We present integral field spectroscopy of X2127+119, the luminous X-ray binary in the globular cluster M15, obtained with INTEGRAL/WYFFOS on the William Herschel Telescope. We find that tomograms of He II λ4686 line profiles appear to be incompatible with the previously-assumed view of X2127+119, in which the binary consists of a 1.4-M⊙ neutron star and a 0.8-M⊙ sub-giant companion near the mai...

Prodrugs of the short-lived chloroethylating agent 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE) and its methylating analogue 1,2-bis(methylsulfonyl)-1-(methyl)hydrazine (KS90) are potentially useful anticancer agents. This class of agents frequently yields higher ratios of therapeutically active oxophilic electrophiles responsible for DNA O(6)-guanine alkylations to other electroph...

Robust, long-lasting immune responses are elicited by memory T cells that possess properties of stem cells, enabling them to persist long-term and to permanently replenish the effector pools. Thus, stem cell-like memory T (TSCM) cells are of key therapeutic value and efforts are underway to characterize TSCM cells and to identify means for their targeted induction. Here, we show that inhibition...

alzheimer’s disease (ad) is a neurodegenerative disease that is the most common type of dementia.ad includes 60_80% of dementia and most people with ad have more than 65 years old.ad causes losing neuronal activity by abnormal proteins. plaques of beta-amyloid and tangles of “tau” protein can lead to ad. recently evidence has found that ad may come from outside of central nervous system (cns) a...

A series of 119 Mycobacterium avium complex isolates were subjected to clarithromycin susceptibility testing using microplates containing 2,3-diphenyl-5-thienyl-(2)-tetrazolium chloride (STC). Among 119 isolates, 114 (95.8%) were susceptible to clarithromycin and 5 were resistant according to the new and the standard method. STC counts the low cost and reduces the number of procedures needed fo...

PERSPECTIVES AND SUMMARY ............................................................................ 117 ELECTROPHYSIOLOGICAL PR PERTIES ............................................................ 119 Time Constants and Noise Analysis .................................................................. 119 Gating Concept .............................................................................

BACKGROUND Universal coverage with long-lasting insecticidal nets (LLINs) is a primary control strategy against Plasmodium falciparum malaria. However, its impact on the three other main species of human malaria and lymphatic filariasis (LF), which share the same vectors in many co-endemic areas, is not as well characterized. The recent development of multiplex antibody detection provides the o...