The use of herbal formulations has gained scientific interest, particularly in cancer treatment. In this study, the herbal formulation of interest, denoted as C168, is a mixture of eight genera of plants. This study aims to investigate the antiproliferative effect of C168 methanol extract (CME) on various cancer cells and its underlying mechanism of action on the most responsive cell line, name...

Akt acts as a pivotal regulator in the PI3K/Akt signaling pathway and represents a potential drug target for cancer therapy. To search for new inhibitors of Akt kinase, we performed a structure-based virtual screening using the DOCK 4.0 program and the X-ray crystal structure of human Akt kinase. From the virtual screening, 48 compounds were selected and subjected to the Akt kinase inhibition a...

AIMS AND BACKGROUND The mechanism of human MutL Homolog (hMLH1) gene transcriptional inactivation in non-small cell lung cancer (NSCLC) is still unclear. The aim of this study is to further investigate the main mechanism of hMLH1 gene inactivation in NSCLC samples of Chinese patients. METHODS AND STUDY DESIGN This study was performed in surgically resected primary tumor and matched normal tis...

collagen molecule, the most abundant protein in the fibrotic matrix. Describing the synthesis of the interstitial collagens, Types I and III, de Crombrugghe et al. outline the complex series of translocation and splicing events that ultimately lead to the transcription of the chick a2(I), oal(I) and al(III) collagen genes. Kivirikko and Majamaa explore the regulation of post-translational modif...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Recen D, Başer A, Yıldırım B. Dental students’ perceptions of distance learning in terms various variables during a transition due to COVID-19. Journal Stomatology. 2021;74(2):116-123. doi:10.5114/jos.2021.106498. APA Recen, D., Başer, A., & Yıldırım, (2021). Stomatology, 74(2), 116-123. https://doi.org/10.5114/jo...

An association between the resistance to mitomycin C (MMC) and a decrease of NAD(P)H:quinone oxidoreductase (NQO1) activity was re ported for a MMC-resistant subline, HCT 116-R3OA,derived from MMC sensitive HCT 116 cells. Eight NQO1 cDNA clones were IsOlated from these two sublines by reverse transcription-PCR. Two clones, pDT9 from HCT 116 and pDT2Ofrom HCT 116-R3OA,are the full length of 274 ...

error group, 54Addelman and Kempthorne, 60adiabatic, 171adiabatic quantum computing, 171adjacency matrix, 94adjoint action, 76, 90amplification, 149annihilation operator, 134annihilator, 49, 50minimal, 50Arthur-Merlin games, 147average Hamiltonian, 44average Hamiltonian theory, 44 Bloch sphere, 33Bloch vector, 33BPP, 31BQP, 30 Carathéo...

Colorectal adenocarcinoma is a common cause death cancer in the whole world. The aim of this study is to define the 111In-cetuximab as a diagnosis tracer of human colorectal adenocarcinoma. In this research, cell uptake, nano-SPECT/CT scintigraphy, autoradiography, biodistribution and immunohitochemical staining of EGF receptor were included. HCT-116 and HT-29 cell expressed a relatively high a...

We report on the development of IMD, a scalable program for classical molecular dynamics simulations on massively parallel supercomputers. New features like online-visualization and metacomputing are described.