Several studies have shown that renal failure decreases CYP3A activity and that uremic toxins may play a role via transcriptional or translational modifications of cytochrome P450 (P450) enzymes and direct inhibition of P450-mediated metabolism. In this study, we evaluated the relationship between CYP3A activity (using plasma concentration of 4b-hydroxycholesterol as a biomarker) and clinical c...

The mode of action of sulfanilyl fluoroquinolones (NSFQs) was investigated with NSFQ-104, NSFQ-105, and some structurally related compounds. Evidence arising from interactions with p-aminobenzoic acid and trimethoprim suggested that a sulfonamidelike mechanism of action makes little or no contribution to the in vitro activity of NSFQs. NSFQ-105 showed an activity that inhibits gyrase-catalyzed ...

This paper provides a comprehensive outline of the audit process advocated for clinical radiologists and clinical radiology departments. The philosophy discussed is equally appropriate for interventional and diagnostic radiologists.

Context: Refactoring is a maintenance task that refers to the process of restructuring software source code to enhance its quality without affecting its external behavior. Inspecting and analyzing the source code of the system under consideration to identify the classes in need of extract subclass refactoring (ESR) is a time consuming and costly process. Objective: This paper explores the abili...

Recent applications of ESR, NMR and ENDOR to the following investigations are briefly reviewed : motional effects of point defects, influence of structural phase transitions on defects, self diffusion, dislocation motion, structure of low symmetry defects, excited states of defects. The application of ENDOR-induced ESR to solid state defects is briefly described. It allows the analysis of super...

ESR conducts annual surveys of methicillin-resistant Staphylococcus aureus (MRSA). Each year, all hospital and community microbiology laboratories in New Zealand are asked to refer all MRSA isolated during a one-month period to ESR. Laboratories provide epidemiological information with each isolate referred. At ESR, MRSA are typed to identify MRSA strains. The purpose of these annual surveys is...

We study the feasibility of autonomous transaction execution in systems with asynchronous transaction processing based on epsilon serializability (ESR). The abstract correctness criteria deened by ESR are implemented by techniques such as asynchronous divergence control and asynchronous consistency restoration. Concrete application examples in a distributed environment, such as banking, illustr...

OBJECTIVES To investigate whether a difference exists between DAS28 from CRP and DAS28 from ESR in patients with rheumatoid arthritis (RA) and secondary Sjögren's syndrome (sSS). MATERIAL AND METHODS One group comprised patients with RA and sSS, the control group comprised patients with RA. The inclusion criteria for the RA and sSS group have been specified as follows: presence of at least on...

OBJECTIVES The aim was to compare continuous and on-demand NSAID treatment with respect to their ability to suppress radiographic progression in subgroups of patients with high/elevated CRP-levels, ESR, ASDAS-levels or BASDAI-levels in comparison to patients with normal levels. METHODS Post-hoc analyses were performed in a randomized trial comparing continuous and on-demand NSAID treatment. R...