The Ren-1 locus of mice encodes the protease renin, which with converting enzyme processes angiotensinogen to the potent vasopressor angiotensin II. Some strains of mice appear to carry a duplication of the renin structural gene (Ren-2) near the Ren-1 locus. Strains with the gene duplication can exhibit as much as 100-fold higher levels of submaxillary gland renin compared to strains with a sin...

AIMS Little evidence is available regarding restrictions from driving following implantable cardioverter defibrillator (ICD) implantation or following first appropriate or inappropriate shock. The purpose of the current analysis was to provide evidence for driving restrictions based on real-world incidences of shocks (appropriate and inappropriate). METHODS AND RESULTS A total of 2786 primary...

Percutaneous endoscopic gastrostomy (PEG) is a method widely used for patients with amyotrophic lateral sclerosis (ALS); nevertheless, its effect on survival remains unclear. The purpose of this meta-analysis study was to determine the effects of PEG on survival in ALS patients. Relevant studies were retrieved from PubMed, EmBase, and the Cochrane Library databases, from inception to June 2017....

The influence of afterload on the rate of force generation by the myocardium was investigated using two types of preparations: the in situ dog heart (dP/dt) and isolated papillary muscle of rats (dT/dt). Thirteen anesthetized, mechanically ventilated and thoracotomized dogs were submitted to pharmacological autonomic blockade (3.0 mg/kg oxprenolol plus 0.5 mg/kg atropine). A reservoir connected...

By employing metastable impact electron spectroscopy (MIES) and ultraviolet photoelectron spectroscopy (UPS) together with work-function measurements, three adsorption states of benzene have been identified on the clean Mo(100) surface at 100 K: a chemisorbed layer, a second physisorbed layer with the aromatic rings plane parallel to the surface, and at higher coverages, an adsorbed layer with ...

Abstract Background The 2018 Infectious Diseases Society of America (IDSA) OPAT guidelines recommend that an outpatient-initiated first dose may be administered at home under the supervision healthcare personnel who are trained to respond IgE-mediated hypersensitivity reactions. This involve a health nurse, but if resources limited, agencies require first-dose infusion completed in monitored se...

In this paper we present a study of the effects caused in distributed real-time systems by the presence of jitter in the activation of tasks and messages. We show that although jitter has usually a small impact in the schedulability of single-processor systems, in distributed architectures the worst-case response times are significantly delayed. Reducing or eliminating jitter in these systems c...