In 2006, Takahashi and Yamanaka reported the breakthrough discovery of induction of pluripotent stem cells from fibroblasts by a combination of defined factors. Ten years later, Cell editor João Monteiro brings together Shinya Yamanaka and Hans Schöler, one the original reviewers of the landmark study, to revisit the history behind the paper and its long-lasting legacy.

Reusing time-tested solutions rather than inventing ad-hoc quick fixes is a wellknown security principle. Architectural and design patterns represent proven techniques to package knowledge from software engineering experts in a reusable format. More importantly, the solution proposed by a pattern is known to be sound because it is time-tested—its strengths, weaknesses and possible drawbacks are...

Throughout our specialty—at meetings, in our journals, and in our clinics—patient safety has become not only a buzzword but an important focus for plastic surgeons. The cover of this month’s Aesthetic Surgery Journal bears a banner reminding us that 2011 marks the 10th anniversary of the first dedicated instructional course in patient safety at the American Society for Aesthetic Plastic Surgery...

When Critical Care's first issue was published we were on the brink of the electronic revolution. In the same year the number of online websites reached 1 million (a mere fraction of the vast resources now available) and for the first time more e-mails were sent than letters [1]. The Internet was swiftly seeping into mainstream use. The initial concept behind Critical Care was to make the most ...

This monthmarks the tenth anniversary of the landmark decision by the International Committee of Medical Journal Editors to make journals require “registration of any clinical trials in a public trials registry at or before the time of first patient enrolment as a condition of consideration for publication.” It has been a long journey. The idea of prospective registration was first suggested in...

The rural, a diminishing global resource, provides us with an increasingly important environment for tourism. On the supply side, its impacts, both positive and negative, are well documented, widely debated and the subjects of an increasing literature. Often overlooked, however, are the benefits to rural visitors, the welfare effects of improved mental and physical well-being that are the widel...