PURPOSE Phase II trials play an essential role in drug development pathway, and their conclusions often impact the decision to embark on large, pivotal trials. However, the determination of agent activity is highly dependent on trial design. Formal comparisons of phase II trial designs across medical specialties are uncommon. We hypothesized that there are significant differences in the design ...

Objective: This study aimed to investigate the association between global DNA and PTEN gene methylation changes type of delivery. Material Methods: The included a total 129 pregnant women at >37th week pregnancy who had cesarean (CS) (n=62) or vaginal delivery (VD) (n=67) their infant's cord blood (n=129). 5-mC ELISA method performed analyses, while change analyses were conducted using methylat...

PURPOSE To investigate the effect of two tinted contact lenses (CL) designed for outdoor sports activity on the psychometric determination of retinal straylight using the compensation comparison method. METHODS Thirteen emmetropic subjects were randomly fitted with two different tinted Nike Maxsight (Bausch & Lomb, Rochester, NY, USA) CL in one eye, while the contralateral eye was fitted with...

Background: The objectives of this study were to compare the graft uptake and post-operative hearing results underlay myringoplasty with temporalis fascia perichondrial-cartilage composite in high risk perforations. Materials & Methods: Patients ages 13 years above diagnosis chronic otitis media – mucosal type perforations undergoing included. Criteria >50% perforation tympanic membrane,...

combining ability and heterosis were studied in a 6×6 partial diallel cross during 2007-2009 to see the nature of gene action in cucumber (cucumis sativus l.). analysis of variance revealed high significant differences among all the f1 hybrid means and among their respective six parental values for all the traits examined. the mean squares attributed to general combining ability (gca) and speci...

The relationship between normal aging and regional cerebral blood flow (rCBF) computed as initial slope index (ISI) by Fourier method was investigated in 105 right-handed healthy volunteers (132 measurements) by Xe-133 inhalation method, and age-matched normal values were calculated. Mean brain ISI values showed significant negative correlation with advancing age (r = 0.70, p less than 0.001), ...