Reaction of 5S RNA with chlorocetaldehyde leads to the conversion of unpaired adenines to the fluorescent 1,N6-etheno-adenine derivatives. Up to 16 of the 23 adenines in free 5S RNA can be modified, the fastest reacting are A29, A34, A57-59. Partial modification of adenines in this area results in a 20% reduction in the efficiency of 5S RNA incorporation into 50S subunits during reconstitution ...

It is based on the intractability of Quadratic Residuosity Assumption modulo a composite N . Very roughly, we select uniformly at random Quadratic Residues from ZN to encrypt 0 bit and to encrypt 1 bit we select quadratic non-residue from ZN . However, since the distribution of quadratic residues and quadratic non-residues are not same in ZN we confine ourselves to a subset of ZN where the numb...

For a one-dimensional local domain CM constructed by Akizuki, we find residue maps which give rise to a local duality. The completion of CM is described using these residue maps. Injective hulls of a given module are all isomorphic. For this reason, people often speak of the injective hull to indicate its “uniqueness”. However, isomorphisms between these injective hulls are not canonical. In fa...

Streptomyces griseus trypsin (SGT) is a bacteria-sourced that could be potentially applied to industrial insulin productions. However, SGT produced by microbial hosts displayed low catalytic efficiency and undesired preference lysine residue. In this study, engineering the α signal peptide in Pichia pastoris, we increased amidase activity 67.91 U mL−1 shake flask cultures. Afterwards, engineere...

P2X receptor channels (P2XRs) are allosterically modulated by several compounds, mainly acting at the ectodomain of the receptor. Like copper, mercury, a metal that induces oxidative stress in cells, also stimulates the activity of P2X(2)R and inhibits the activity of P2X(4)R. However, the mercury modulation is not related to the extracellular residues critical for copper modulation. To identif...

For a one-dimensional local domain CM constructed by Akizuki, we find residue maps which give rise to a local duality. The completion of CM is described using these residue maps. Injective hulls of a given module are all isomorphic. For this reason, people often speak of the injective hull to indicate its “uniqueness”. However, isomorphisms between these injective hulls are not canonical. In fa...

The Auslander-Reiten conjecture is a notorious open problem about the vanishing of Ext modules. In Cohen-Macaulay complete local ring R with parameter ideal Q, holds for if and only it residue R/Q. former part this paper, we study R/Qℓ in connection that R, prove equivalence them case where Gorenstein ℓ≤dim⁡R. latter part, generalize result minimal multiplicity by J. Sally. Due to these two our...

In superior cervical ganglion neurons, N-(piperidiny-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) competitively antagonizes the Ca(2+) current effect of the cannabinoid (CB) agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone (WIN55212-2), and behaves as an inverse agonist b...