The chemistry of α-(arylhydrazono)-β-ketoaldehydes has recently received considerable attention and they are frequently employed as synthons in organic synthesis their structural features part biologically active compounds. Thus, the present studies research describe novel series 3,3'-(5-methyl-1-phenyl-1H-pyrazole-3,4-diyl)bis(2-arylhydrazono-3-oxo-propanal) 3a-i via coupling re...

The biheterocyclic derivative of the phosphonic glycine analogue is prepared selectively by reaction between α-azidoamino diethyl methylphosphonate and 1-(prop-2-yn-1-yl)-1H-benzo[d]imidazole. dipolar -1,3 cycloaddition using Click Chemistry was carried out in a solvent water/ethanol mixture ratio 1:1. Copper sulphate pentahydrate sodium ascorbate are used catalytic amounts. compound [diethyl [...

In the mol-ecule of the title compound, C7H9N3O3, the nitro and carbonyl groups are tilted with respect to the imidazole ring by 9.16 (6) and 65.47 (7)°, respectively. Neighbouring chains are linked via C-H⋯N and C-H⋯O hydrogen bonds forming two-dimensional slab-like networks lying parallel to (01-1).

Six impurities in pantoprazole sodium bulk drug substance were detected by a simple high performance liquid chromatographic method (HPLC) whose area percentage ranged from approximately 0.05 to 0.34%. Liquid chromatography-mass spectrometry (LC-MS) was performed to identify the molecular weight of the impurities. A thorough study was undertaken to characterize these impurities. These impurities...

New novel derivatives of N-((5-((6-oxido-6-(4 substituted phenoxy)-4,8-dihydro-1H-[1,3,2] dioxaphosphepino [5,6-c]pyrazol-1-yl) methyl)-1,3,4-thiadiazol-2-yl)carbamoyl) substituted benzene sulfo namides (7a-o as depicted in scheme) were Synthesized by condensation reaction of 4substituted Phenyl phosphorodichloridates (6a-c) and N-((5-((4,5-bis(hydroxymethyl)-1H-pyrazol-1-yi)methyl)1,3,4-thiadi...