We used the Robotic Optical Transient Search Experiment (ROTSE-III) astrophysical transient survey to determine the rate of type Ia supernovae (SNe Ia) in dwarf galaxies within a radius of 310 Mpc. The rate is inferred from the SNe Ia sample discovered by ROTSE-III and a Monte Carlo simulation that estimates the ROTSE-III SNe Ia detection efficiency. Assuming that the rate of SNe Ia is the same...

OBJECTIVE To compare the sensitivity and specificity of luciferase immunoprecipitation (LIPS) with radioimmunoprecipitation (RIP) for the measurement of autoantibodies to the type 1 diabetes autoantigens glutamic acid decarboxylase 65 (GAD65) and insulinoma-associated protein (IA)-2beta. RESEARCH DESIGN AND METHODS Sera from 49 type 1 diabetic patients and 100 nondiabetic control subjects fro...

B lymphocytes are equipped with a receptor for the recognition of the Fc part of IgG (1, 2) which is not identical to the surface Ig receptor (3). Dickler and Sachs (4) found that anti-Ia antibodies inhibit the binding of aggregated IgG to this receptor, whereas anti-H2D or K antibodies did not have the same effect. On the other hand, Schirrmacher et al. (5) found that also antibodies against o...

Insulinoma-associated protein 2 (IA-2) is the major autoantigen that contributes to the pathogenesis of type 1 diabetes (T1D). IA-2-deficient (IA-2-/-) mice showed impaired insulin secretion after intraperitoneal injection of glucose as well as elevated glucose level in a glucose tolerance test. Despite the fact that 70% of newly diagnosed T1D patients have an antibody against IA-2, the role of...

Recent studies of low redshift type Ia supernovae (SN Ia) indicate that half explode from less than Chandrasekhar mass white dwarfs, implying ignition must proceed from something besides the canonical criticality of Chandrasekhar mass SN Ia progenitors. We show that 1-100 PeV mass asymmetric dark matter, with imminently detectable nucleon scattering interactions, can accumulate to the point of ...

The morphology of filamentous fungi closely correlates with the productivity in submerged culture. Using itaconic acid (IA) production by Aspergillus terreus as a research model, the quantitative relationship between the growth form of A. terreus and IA production was investigated. IA fermentation was scaled up from shake flasks to a 7 L stirred tank bioreactor based on the quantitative relatio...

The two known estrogen receptors, ER and ER , are hormone-inducible transcription factors that have distinct roles in regulating cell proliferation and differentiation. Previously, our laboratory demonstrated that ER exhibits stereoselective ligand binding and transactivation for several structural derivatives and metabolites of the synthetic estrogen diethylstilbestrol. We have previously desc...

BACKGROUND AND PURPOSE Although intravenous (IV) thrombolysis is the standard treatment for patients with ischemic stroke occurring within 3 hours from symptom onset, a few interventional neuroradiologists have been treating this category of patients by an intra-arterial (IA) route for >25 years. However, evidence is still required to support the clinical feeling that IA treatment, which needs ...

The use of type Ia supernovae (SNe Ia) as cosmological standard candles is fundamental in modern observational cosmology. In this letter, we derive a simple empirical photometric redshift estimator for SNe Ia using a training set of SNe Ia with multiband (griz) light-curves and spectroscopic redshifts obtained by the Supernova Legacy Survey (SNLS). This estimator is analytical and model-indepen...

H-2 antigens are expressed in substantial amounts of murine blood platelets (for H-2 antigenic content 1 lymphocyte approximately 50 platelets) whereas Ia antigens are probably not expressed at all (minimal Ia antigenic content more than 35 times lower than for H-2). This property of blood platelets makes them very useful for the selective absorption of anti-H-2 antibodies from complex sera and...