BACKGROUND Endothelin-1 (ET-1) inhibition of vasopressin (AVP)-stimulated water reabsorption by the inner medullary collecting duct (IMCD) is associated with reduced cAMP accumulation. To determine the effect of ET-1 deficiency, AVP-stimulated cAMP responsiveness was assessed in IMCD from mice with collecting duct-specific deletion of ET-1 (CD ET-1 KO) and from control animals. METHODS Cyclic...

OBJECTIVE(S) The aim of this work was to investigate the effect of the natural and the chemically modified form of cyclodextrins namely; β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) respectively on the solubility and dissolution rate of aripiprazole; an antipsychotic medication showing poor aqueous solubility. MATERIALS AND METHODS Phase solubility of aripiprazole with the...

Collecting duct (CD) endothelin-1 (ET-1) is an autocrine inhibitor of Na+ and water reabsorption. Salt or water loading increases CD ET-1 production; this is likely due, at least in part, to increased tubule fluid flow. The mechanisms by which flow stimulates CD ET-1 production are incompletely understood. In particular, flow induction of cortical CD (CCD) and inner medullary CD (IMCD) ET-1 syn...

The application of Cd inhibited the development of mycelia of the saprobe fungi Fusarium concolor and Trichoderma koningii and the hyphal length of the arbuscular mycorrhizal fungi Glomus mosseae and G. deserticola in vitro. The application to soil of 25 and 50 mg l–1 of Cd decreased the shoot dry weight, the percentage of AM root length colonization and the succinate dehydrogenase activity of ...

The effect of a chemically stable prostacyclin analog, OP-41483 alpha-cyclodextrin clathrate (OP-41483.alpha-CD), on vascular lesions, platelet aggregation and blood pressure were examined and compared with those of prostaglandin E1 alpha-cyclodextrin clathrate (PGE1.CD) in in vivo rat models. 1) In the laurate (1 mg/leg, i.a.)-induced arterial thrombotic model, OP-41483.alpha-CD (1 microgram/k...

Solvent-mediated crystal-to-crystal transformations of [Au6Ag3Cu3(H2O)3(d-pen)6(tdme)2]3+ (d-[1(H2O)3]3+; pen2−=penicillaminate, tdme=1,1,1-tris(diphenylphosphinomethyl)ethane) to form unique supramolecular species are reported. Soaking crystals d-[1(H2O)3]3+ in aqueous Na2bdc (bdc2−=1,4-benzenedicarboxylate) yielded containing d-[1(bdc)(H2O)2]+ due the replacement a terminal aqua ligand by mon...

the isolated perfused rat liver (iprl) model has been used into toxicology study of rat liver. this model provides an opportunity at evaluation of liver function in an isolated setting. studies showed that cd, in a dose-dependent manner, induced toxic effects in iprl models, and these effects were associated with aminotransferase activity and lipid peroxidation. the aim of this study was to inv...

Electrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating β-cyclodextrin inclusion complex (β-CD-IC) of quercetin (QU) was performed. Here, β-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry o...

Amphiphilic γ-cyclodextrin–fullerene 2:1 complexes (C L FC H complexes) were prepared by high-speed vibration milling of lipophilic tail-grafted γ-cyclodextrin (γ-CD), hydrophilic γ-CD and fullerene C 60 . The transamidation γ-CD–fullerene complex having two...

The following result was proved by Bárány in 1982: For every d ≥ 1 there exists cd > 0 such that for every n-point set S in R d there is a point p ∈ R contained in at least cdn d+1 −O(n) of the d-dimensional simplices spanned by S. We investigate the largest possible value of cd. It was known that cd ≤ 1/(2(d+ 1)!) (this estimate actually holds for every point set S). We construct sets showing ...