A new, rapid, economical and isocratic reverse phase high performance liquid chromatography (RP-HPLC) method was developed for the determination of eptifibatide acetate, a small synthetic antiplatelet peptide, in bulk drug substance and pharmaceutical dosage forms. The developed method was validated as per of ICH guidelines. The chromatographic separation was achieved isocratically on C18 colum...

PURPOSE To compare three different treatment modalities for traumatic corneal abrasions. METHODS We conducted a prospective, randomized, masked, three-arm clinical study of patients presenting with superficial corneal foreign bodies. Treatment modalities were: (1) pressure patching with ofloxacin ointment (patch group, PG, n = 18), (2) therapeutic contact lens with ofloxacin eye drops (contac...

BACKGROUND AND METHODS Hypertension is a common problem in hemodialysis (HD). However, its behavior during the interdialytic period is not completely known and is infrequently monitored in clinical practice. Thus, for better understanding of interdialytic blood pressure (BP), we analyzed the interdialytic blood pressure profile using 44-hour ambulatory blood pressure monitoring (ABPM) data in 7...

Crude wild pear lipoxygenase (LOX) from ripe Kurdistan wild pears was used in this study. Extracted crude LOX was assayed spectrophotometrically for raw, ripe wild pear lipoxygenase and after 7-day storage. The effects of different buffers and pHs, substrate preparations, temperature, inhibitors and metal ions on LOX activity were evaluated at three conditions. The enzyme was most active with H...

background: this work aimed to show and compare the degradation time of some of cartilage extracellular matrix components using an in vitro model for cartilage degradation induced by interleukin-1 alpha. it is known that elucidation of molecular events under interleukin-1 alpha induction of bovine nasal cartilage could obtain useful data to understand more about involving mechanisms for tissue ...

Background: In this work investigation of the normoxic PAGAT polymer gel dosimeter such as sensitivity, the R2-dose response with post time and the percentage depth dose (PDD) of PAGAT polymer gel dosimeter have been undertaken. Materials and Methods: Using MRI, the formulation to give the maximum change in the transverse relaxation rate R2 was determined to be 4.5% N,N'-methylenbis- ...

PURPOSE To investigate prostatic organ motion at both setup and intrafraction using an onboard image-guided system. An intrafraction field-based repositioning method also was evaluated. MATERIALS AND METHODS A dual fluoroscopy with amorphous-silicon flat panel (DFFP) system was used for the three-dimensional registration of implanted markers in the prostate of eight organ-confined cancer pati...

background: the aim of this study was to evaluate the efficacy and safety of a recombinant human follicle stimulating hormone (r-fsh) low-dose step-up regimen for controlled ovarian hyperstimulation in patients undergoing ovulation induction (oi) with intrauterine insemination (iui). materials and methods: the study was conducted in the department of obstetrics and gynecology, far eastern memor...