Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the n...

Received: Revised: Accepted: 2013–09–15 2013–09–2

*Study carried out in the Departments of Pulmonology and Thoracic Surgery of the Instituto do Coração Hospital das Clínicas da Faculdade de Medicina da Univerdidade de São Paulo (InCor – HC FMUSP, Clinical Hospital Heart Institute of the University of Sâo Paulo School of Medicine) Correspondence to: Rua Pintassilgo, 519 apt. 80, CEP: 04514-032 – São Paulo SP. Phone #: 55-11-5093 8775. E-mail:pn...

It is argued that there is a disjunction between conservation and modern architectural theories with regards to the concept of space. The argument is developed through a case study, the Casa de Detenção do Recife, a XIX Century listed penitentiary, whose restoration demonstrates how subtle spatial changes can alter building’s properties. The paper concludes by proposing a new approach to archit...

Introduction FMF is considered an autosomal recessive autoinflammatory syndrome caused by single gene (MEFV) mutations. Recently, it has been known that also heterozygous mutation carriers can suffer from a mild or incomplete form of FMF, named FMF-like disease. Among Armenians, who have relatively high carrier rate of MEFV mutations, single mutation has been detected in about 1/5 of symptomati...

First-literal hyper-resolution (FLH) is a reenement of ordinary hyper-resolution in that positive clauses are only resolved upon their rst literals. In this respect, positive literals are ordered in every clause, but negative literals are not. Due to the ordering of literals in this resolution method, standard techniques for demonstrating ground completeness have proven ineeective. In this pape...