The anticancer activities of ginsenosides are widely reported. The structure-activity relationship of ginsenosides against cancer is not well elucidated because of the unavailability of these compounds. In this work, we developed a transformation method to rapidly produce rare dehydroxylated ginsenosides by acid treatment. The optimized temperature, time course, and concentration of formic acid...

Objective(s): Colon cancer is risen up with its complex mechanism that directly impacts on its treatment as well as its common prevalence. Mesenchymal stem cells (MSCs) have been considered as a therapeutic candidate for conventional disease including cancer. In this research, we have focused on apoptotic effects of adipose tissue-derived MSCs in colon cancer.Materials and Methods: MSCs were ob...

The utility of [(18)F]WC-4-116, a PET tracer for imaging caspase-3 activation, was evaluated in an animal model of myocardial apoptosis. [(18)F]WC-4-116 was injected into rats at 3 hours after a 30 min period of ischemia induced by temporary occlusion of the left anterior descending coronary artery in Sprague-Dawley rats. [(18)F]WC-4-116 uptake was quantified by 1) autoradiography, 2) microPET ...

BACKGROUND Cells release extracellular membrane vesicles including microvesicles known as exosomes. Exosomes contain microRNAs (miRNAs) however the full range within colorectal cancer cell secreted exosomes is unknown. OBJECTIVE To identify the full range of exosome encapsulated miRNAs secreted from 2 colorectal cancer cell lines and to investigate engineering of exosomes over-expressing miRN...

In a prospective follow up of 116 high risk infants, a 24 hour behavioural chart on seven consecutive days was analysed at seven and 12 weeks of age. Of children who manifested atopic disease at 2 years, 44/116 (38%), had shown significantly more fussing during the seventh, and colic type cry during the twelfth week than those who remained healthy (72/116, 62%).

Objective: The anti-cancer effect and mechanism of N1,N3-bis(3-methoxysalicylidene) diethylenetriamine (Valdien) in HCT-116 cells were assessed in this study. Methods: MTT was used to measure cytotoxicity of the Valdien. The appearance of apoptotic HCT-116 cells was detected by flow cytometry analysis. Apoptosis proteins, caspase family and Bcl-2 family were viewed by Western blotting. The Wnt1...

Dariush Ilghari, Kirsty L. Lightbody, Vaclav Veverka, Lorna C. Waters, Frederick W. Muskett, Philip S. Renshaw and Mark D. Carr Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester, LE1 9HN, U.K. Running title: Solution structure of M. tuberculosis EsxG•EsxH complex * To whom correspondance should be addressed: Prof. Mark Carr, Tel. (+44) 116 229 7075; Fax (+4...