نتایج جستجو برای: گیرنده a1 آدنوزینی
تعداد نتایج: 28872 فیلتر نتایج به سال:
Here we report the genomic cloning and characterization of the murine A1 genes, which belong to the bcl-2 gene family. Southern analysis indicated the existence of at least four A1 genes in the murine genome and four different A1 genes, designated A1-a, -b, -c and -d, were cloned from the murine genomic library. The A1-a, -b and -d genes consisted of two exons, whereas the A1-c gene contained 1...
Six compounds were isolated from Derris laxiflora Benth., including two new pterocarpans, 7,6'-dihydroxy-3'-methoxypterocarpan (1) and derrispisatin (2), as well as four known ones, lespedezol D, (3), secundiflorol 1 (4), 6a-hydroxymaackiain (5) and pisatin (6). The structures of these compounds were determined by analysis of their spectroscopic data.
چکیده هدف: اعمال تحریکات الکتریکی با فرکانس پایین (low-frequency stimulation; lfs) اثر مهاری بر روند کیندلینگ دارد. مطالعات قبلی نشان داده که این اثرات مهاری تا حدی وابسته به فعالیت گیرنده های آدنوزینی است. در مطالعه حاضر نقش مسیر های مختلف موثر در تولید و حذف آدنوزین و نقش آنها در اعمال lfs مورد بررسی قرار گرفت. مواد و روش ها: حیوانات با تحریک الکتریکی (12 بار در روز) مسیر پرفورنت کیندل شدن...
Most individuals carry two wild-type M alleles of the SERPINA1 gene which encodes a1-antitrypsin. 95% of severe deficiency of a1-antitrypsin is associated with the Z allele (Glu342Lys; denoted PiZZ in the homozygote), and with the retention and polymerisation of a1-antitrypsin within hepatocytes [1]. These polymers are contained within periodic acid–Schiff-positive, diastase-resistant inclusion...
OBJECTIVE Multiple sclerosis (MS) is the most common demyelinating disorder of the central nervous system (CNS). Data suggest that antibodies to CNS targets contribute to the pathogenesis of MS. MS patients produce autoantibodies to heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1). hnRNP A1 is an RNA binding protein (RBP) overexpressed in neurons that functions in pre-mRNA splicing, mRNA t...
Previously (9), I found that immunization of rabbits with antibody directed against variable region heavy chain VH polypeptides of a1 allotype induced the production of antiidiotype (anti-Id) molecules that appeared to bear images of the original a1 allotype. I now show that these anti-Id molecules can be fractionated into two populations: one population (a2a3- anti-Id) that lacks the nominal V...
Cyclin A1 differs from other cyclins in its highly restricted expression pattern. Besides its expression during spermatogenesis, cyclin A1 is also expressed in hematopoietic progenitor cells and in acute myeloid leukemia. We investigated mechanisms that might contribute to cyclin A1 expression in hematopoietic cells. Comparison of cyclin A1 and cyclin A promoter activity in adherent and myeloid...
Let Pn denote the set of all algebraic polynomials of degree at most n with real coefficients. Associated with a set of poles {a1, a2, . . . , an} ⊂ R\ [−1, 1] we define the rational function spaces Pn(a1, a2, . . . , an) := 8< : : f(x) = b0 + n X j=1 bj x− aj , b0, b1, . . . , bn ∈ R 9= ; . Associated with a set of poles {a1, a2, . . . } ⊂ R\[−1, 1] , we define the rational function spaces P(a...
The quest for novel therapeutic targets in acute myeloid leukemia (AML) is still ongoing. One of such targets, cyclin A1, was shown to be overexpressed in AML including AML stem cells. However, the function of cyclin A1 in AML is largely unknown, and the data on its impact on patients' survival remain controversial. Therefore, we developed a transgenic mouse model of stem cell-directed inducibl...
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