Platelet counts in blood are controlled by the rates of their production by megakaryocytes and the kinetics of their removal. Alterations in either process can lead to thrombocytopenia (TCP) or thrombocytosis. Under conditions of TCP, the spleen and liver are the sites for accelerated platelet destruction, and in thrombocytosis, the spleen can become a supplemental breeding ground for megakaryo...

Previous studies have shown that the recognition accu racy often severely degrades at higher speech rates which can basically be traced back to two main dimensions acoustic and phonemic Reasons for this e ect can be found in the phonemic eld e g elisions as well as on the acoustic level with increasing rates of speech the spec tral characteristics are changing A main obstacle in this context is...

This paper introduces and formalizes homomorphic proofs,which allow ’adding’ proofs and ’adding’ their statementsto get a new proof of the ’sum’ statement. We proposea construction of homomorphic proofs and show one of itsapplications which is a new accumulator scheme with del-egatable non-membership (NM) proofs. We use this accu-mulator in extending the BCCKLS scheme [3...

Former p~pers from this laboratory indicate that the penetration of a weak base, ammonia,* and of a strong base, guanidine, 2 is probably preceded by a chemical reaction with a constituent of the protoplasm. On the other hand the penetration of a weak acid, hydrogen sulfide, s appears to take place by simple diffusion of molecular hydrogen sulfide through the non-aqueous protoplasm. What is the...

makes such studies possible. These cells meet the requirements for quantitative determinations of osmotic phenomena and of the related property of permeability : they are obtainable as isolated un injured cells of a single type; they are free to undergo volume changes; their size and shape is such as to permit accurate measurements. Such characteristics are shared by only a few other types of a...

To ensure consistent good quality grape yields it is necessary to minimize losses associated with affection of plants by various dis-eases. One the main conditions effective control phyto-pathogens a timely monitoring, revealing and assessing harmful or-ganisms development intensity. In modern research, in order improve accuracy reliability quantitative characteristics disease devel-opment inte...

The 2.nitroimidazolemisonidazole(Ro-07-0582)is a hy poxic cell radiosensitizer currently undergoing clinical investigation.In additionto its radiosensitizingabilities,it showsan Increasedtoxicitytowardhypoxiccomparedto aerobic cells. Human HeLa cells are 2 to 3 times more sensitive to misonidazole in terms of the time required to reduce survival to 0.1% after hypoxic incubations in 5 mis drugth...

We consider multi-label classification problems in application scenarios where classifier accu-racy is not satisfactory, but manual annotation is too costly. In single-label problems, a wellknown solution consists of using a reject option, i.e., allowing a classifier to withhold unreliabledecisions, leaving them (and only them) to human operators. We argue that this solution can be<...

Protein synthesis and protein degradation were measured in human NHIK 3025 cells cultured in vitro during and after an acute treatment of extreme hypoxia (<4 ppm O:). Furthermore, total protein content per cell was recorded and related to cell cycle phase by coincident measure ment of DNA and protein using two-parametric flow cytometry. During hypoxia protein synthesis was reduced and protein d...

The role of vascular permeability in the preferential accumulation of photosensitize» in tumor tissue was investigated. Two murine tumors [experimental mammary tumor carcinoma (EMT-6) and methylcholanthrene-induced rhabdomyosarcoma (MIS)] and a human bladder carci noma (EJ) were grown s.c. on the flank in athymic nude mice and analyzed for in vivo vessel permeability, vascular permeability fac...