Two rhesus monkeys were required to emit 1 to 16 responses (FR 1, 2, 4, 8, and 16) per 0.5 ml delivery of either 8% (w/v( ethanol or water. Ethanol had been established as an effective reinforcer via the oral route in an earlier experiment [4]. At FR 16, responding maintained by ethanol clearly exceeded responding maintained by water for both monkeys. The volume of ethanol intake per session re...

Pharmacokinetic properties of WF-3681 and FR-62765 in rats were examined. FR-62765 showed higher peak concentrations in the plasma and higher concentrations in the sciatic nerve than WF-3681 when each compound was administered orally to rats. We therefore evaluated FR-62765 in rats with diabetic neuropathy. As a result, FR-62765 at 32 mg/kg/day administered for 3 weeks to streptozotocin-induced...

In Distributed Storage Systems (DSSs), usually, data is stored using replicated packets on different chunk servers. Recently a new paradigm of Fractional Repetition (FR) codes have been introduced, in which, data is replicated in a smart way on distributed servers using a Maximum Distance Separable (MDS) code. In this work, for a non-uniform FR code, bounds on the FR code rate and DSS code rate...

A new transplantable ovarian tumor model is presented using a novel folate receptor (FR) positive, murine ovarian cancer cell line that emulates the human disease and induces widespread intraperitoneal (i.p.) tumors in immunocompetent mice within 4-8 weeks of implantation. Tumor development was monitored using a new positron emission tomography (PET) FR-targeting reporter with PET/computerized ...

Flow cytometry (FCM) is a fluorescence-based single-cell experimental technology that is routinely applied in biomedical research for identifying cellular biomarkers of normal physiological responses and abnormal disease states. While many computational methods have been developed that focus on identifying cell populations in individual FCM samples, very few have addressed how the identified ce...

Near wakes behind a sphere in both homogeneous and linearly stratified background were studied numerically and experimentally at Reynolds number Re ≤ 1000, Froude number Fr ≥ 0.5. In a homogeneous fluid, the structural transitions with increasing Re are consistent with previous studies. The stratified results from simulations and experiments are in good agreement. Stratified wakes undergo simil...

The folate receptor (FR) is overexpressed on a variety of tumor types, whereas its distribution in normal tissues and organs is highly limited. Exploration of the utility of the FR revealed its promising potential for targeting with folate-based radiopharmaceuticals. Herein, we report the principle of the FR-targeting strategy and summarize the development of several folic acid radioconjugates ...

Our earlier efforts to document the cortical connections of the ventral premotor cortex (PMv) revealed dense connections with a field rostral and lateral to PMv, an area we called the frontal rostral field (FR). Here, we present data collected in FR using electrophysiological and anatomical methods. Results show that FR contains an isolated motor representation of the forelimb that can be diffe...

Developmental responses associated with end-of-day far-red light (EOD-FR) signaling were investigated in maize (Zea mays subspecies mays) seedlings. A survey of genetically diverse inbreds of temperate and tropical/semitropical origins, together with teosinte (Zea mays subspecies parviglumis) and a modern hybrid, revealed distinct elongation responses. A mesocotyl elongation response to the EOD...

With the aim of exploring the properties of the class of FR 0 radio galaxies, we selected a sample of 108 compact radio sources, called FR0CAT, by combining observations from the NVSS, FIRST, and SDSS surveys. We included in the catalog sources with redshift ≤ 0.05, with a radio size . 5 kpc, and with an optical spectrum characteristic of low-excitation galaxies. Their radio luminosities at 1.4...