The cardiac neural crest (cNC) lineage plays key roles in heart development by directly contributing to heart structures and regulating development of other heart lineages. The basic helix-loop-helix factor Hand2 regulates development of cardiovascular structures and NC-derived tissues including those that contribute to face and peripheral nervous system. Although Hand2 is expressed in cNC, its...

The type 1 alpha regulatory subunit (R1alpha) of cAMP-dependent protein kinase A (PKA) (PRKAR1A) is an important regulator of the serine-threonine kinase activity catalyzed by the PKA holoenzyme. Carney complex (CNC) describes the association 'of spotty skin pigmentation, myxomas, and endocrine overactivity'; CNC is in essence the latest form of multiple endocrine neoplasia to be described and ...

As an innovative and cost-effective method for carrying out multiple-axis CNC machining, 3 1 2 1 2 -axis CNC machining technique adds an automatic indexing/rotary table with two additional discrete rotations to a regular 3-axis CNC machine, to improve its ability and efficiency for machining complex sculptured parts. In this work, a new tool path generation method to automatically subdivide a c...

We fabricated self-standing films of cellulose nanocrystals (CNC) and electrospun composite fibers with CNC and polyvinyl alcohol both with magnetic properties arising from cobalt iron oxide nanoparticles in the CNC matrix. Aqueous dispersions of cobalt-iron oxide nanoparticles (10–80 nm diameter) and CNCs (ca. 150 nm length) were used as precursor systems for the films and composite fibers. Th...

We present a programming methodology and runtime performance case study comparing the declarative data flow coordination language S-NET with Intel’s Concurrent Collections (CnC). As a coordination language S-NET achieves a near-complete separation of concerns between sequential software components implemented in a separate algorithmic language and their parallel orchestration in an asynchronous...

Poly(L-lactide) (PLLA) is a semicrystalline thermoplastic which belongs to a biocompatible, biodegradable and bioresorbable polymers. PLLA also fulfills many requirements of the traditional nonbiodegradable packaging materials and it is therefore considered of great value from an ecological point of view due to its biobased character. Nonetheless, there are several aspects such as its slow crys...

The testing devices for performance testing on a CNC machine tool were developed. A small-radius contouring device was employed for checking the dynamic performance of a CNC machine tool. This device was composed of a laser diode and a quadrant sensor. For checking geometric error of a CNC machine tool, a long-radius contouring device was employed. The optic encoder contouring systems were also...

CNC machining is known as an advanced machining process increasingly used for modern materials. This paper outlines modeling methodology applied to optimize cutting parameters during CNC milling with ball end mill tool. The parameters taken into account were radial depth of cut and feed per tooth. A predictive model was based on artificial neural network approach. Key-Words: Modeling, artificia...