Repetition suppression (RS) is a reduction of neural response that is often observed when stimuli are presented more than once. Many functional magnetic resonance imaging (fMRI) studies have exploited RS to probe the sensitivity of cortical regions to variations in different stimulus dimensions; however, the neural mechanisms underlying fMRI-RS are not fully understood. Here we test the hypothe...

Circumstances that compromise efficient DNA replication, such as disruptions to replication fork progression, cause a state known as DNA replication stress (RS). Whereas normally proliferating cells experience low levels of RS, excessive RS from intrinsic or extrinsic sources can trigger cell cycle arrest and senescence. Here, we report that a key driver of RS-induced senescence is active downr...

BACKGROUND/PURPOSE To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI). METHODS Brain MRI fluid-attenuated inversion-recovery (FLAIR) sequences were performed in 32 multiple sclerosis (MS) patients. Expanded Disability Status Scale (EDSS) score (mean±standard deviation) was 2±2.0 (range 0-8), disease duration 9.3±8.0 (range .8-29) ...

0146 In our recent Letter there appeared several errors in printing. On p. 573, the title should read as follows: ‘‘Diffraction tomography for biomedical imaging with diffuse-photon density waves.’’ Notice that it is biomedical not biochemical. On p. 573, line 6 in the second paragraph in the left-hand-side column, ‘‘In this Letter present a . . .’’ should read as ‘‘In this Letter we present a ...

Between 2001–2003 Paik and others, from a US-based multiinstitutional clinical trials group (the NSABP) that includes many Canadian centres, developed an assay to identify 21 genes from tumour samples that collectively significantly predicted patients’ outcomes (recurrences, breast cancer deaths, and response to chemotherapy).1 The 21-gene assay was based on advances in genetic techniques, refi...

OBJECTIVES To present a case of endodontic failure obturated with a methacrylate-based root filling material, Resilon/RealSeal (RS). To determine if RS is susceptible to biodegradation by endodontically relevant microbes by a method known to show RS degradation. METHOD AND MATERIALS Emulsions of RS were dispersed in agar with minimal bacterial nutrients in culture plates. Lipase PS served as ...

Cannabinoid receptors (CBRs) belong to the G protein-coupled receptor superfamily, and activation of CBRs in salivary cells inhibits agonist-stimulated salivation and modifies saliva content. However, the role of different CBR subtypes in acinar cell physiology and in intracellular signalling remains unclear. Here, we uncover functional CB(1)Rs and CB(2)Rs in acinar cells of rat submandibular g...

Repetition suppression (RS) is a reduction of neural response that is often observed when stimuli are presented more than once. Many functional magnetic resonance imaging (fMRI) studies have exploited RS to probe the sensitivity of cortical regions to variations in different stimulus dimensions; however, the neural mechanisms underlying fMRI-RS are not fully understood. Here we test the hypothe...

BACKGROUND The aim of this study was to assess reliability and validity of the Resilience Scale 11 (RS-11) and develop a shorter scale in a population-based study. METHODS The RS-11 scale was administered to 3942 participants (aged 64 - 94 years) of the KORA-Age study. To test reliability, factor analyses were carried out and internal consistency (Cronbach's α) was measured. Construct validit...

It has been proposed that painful and non-painful referred sensations (RSs) are associated with reorganization of sensory pathways in patients with complete spinal cord injury (SCI). In order to investigate the referred sensation (RS) phenomenon and its correlation with neuropathic pain (NP) 48 patients with complete SCI, 24 with chronic NP and 24 without pain or paraesthesias were studied usin...