The aim of the present was to evaluate the effects of DNA methylation and histone acetylation on 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin (TCDD)‑induced cleft palate in fetal mice. Pregnant mice (n=10) were randomly divided into two groups: i) TCDD group, mice were treated with 28 µg/kg TCDD on gestation day (GD) 10 by oral gavage; ii) control group, mice were treated with an equal volume of corn oi...

Compliance with primary surgical treatment in people with cleft lip and palate is a well-known problem, especially in developing countries fraught with poverty and ignorance. Different protocols of treatment exist. In this paper, we retrospectively review a cohort from two centres, with a discussion on the outcome and its implications. The records of all patients with cleft lip and palate seen ...

OBJECTIVE To determine the interrater reliability of drug-induced sleep endoscopy (DISE). DESIGN Prospective cohort; blinded comparison. SETTING Academic referral center. PARTICIPANTS Subjects with obstructive sleep apnea unable to tolerate positive airway pressure therapy. INTERVENTIONS Drug-induced sleep endoscopy was performed with intravenous propofol infusion to achieve sedation, a...

Cleft palate is one of the most common congenital birth defects worldwide. The homeobox (Hox) family of genes are key regulators of embryogenesis, with Hoxa2 having a direct role in secondary palate development. Hoxa2-/- mice exhibit cleft palate; however, the cellular and molecular mechanisms leading to cleft palate in Hoxa2-/- mice is largely unknown. Addressing this issue, we found that Hoxa...

Proper patterning and growth of oral structures including teeth, tongue, and palate rely on epithelial-mesenchymal interactions involving coordinated regulation of signal transduction. Understanding molecular mechanisms underpinning oral-facial development will provide novel insights into the etiology of common congenital defects such as cleft palate. In this study, we report that ablating Wnt ...

Development of the mammalian secondary palate involves multiple steps of highly regulated morphogenetic processes that are frequently disturbed during human development, resulting in the common birth defect of cleft palate. Neither the molecular processes governing normal palatogenesis nor the causes of cleft palate is well understood. In an expression screen to identify new transcription facto...

Background: Cleft lip and/or palate are the most common orofacial malformations. Many studies, especially in developed countries have been conducted on this malformation, but in Burkina Faso, data are scarce and they are not specific to children. The aim of this study was to report the epidemiological, clinical and therapeutic aspects of cleft lip and/or palate in children in a low-income count...

Nonsyndromic cleft lip & palate is a congenital deformity of multifactorial origin. Various etiologic candidate genes have been reported with conflicting results, according to the race and population studied. Numerous efforts made understand etiology cleft/palate so as predict its occurrence thus enable prevention. The FGF regulation pathway also plays major role in craniofacial development. FG...

Introduction: Cleft lip and palate, the most common developmental deformity, is seen worldwide and the etiology involves a combination of genetic and environmental factors. The purpose of this study was to determine the maternal risk factors associated with the development of cleft lip and cleft palate. Materials and Methods: We conducted a case control study at the Women’s Hospital in Culiacan...