نتایج جستجو برای: ژن srf

تعداد نتایج: 17675  

Journal: :Experimental cell research 2013
Carter A Herndon Nick Ankenbruck Bridget Lester Julie Bailey Larry Fromm

Muscle spindles are sensory receptors embedded within muscle that detect changes in muscle length. Each spindle is composed of specialized muscle fibers, known as intrafusal muscle fibers, along with the endings of axons from sensory neurons that innervate these muscle fibers. Formation of muscle spindles requires neuregulin1 (NRG1), which is released by sensory axons, activating ErbB receptors...

حیدری, رضا, سومباتی, سامپونگ, شاهین, فرزانه, لورنزو, ر ج دی,

در این گزارش ما اثر عصاره آبی (Aqeous fraction (AF)) جدا شده از جدوار با نام علمی Delphinium denudatum WALL.ex Hook.F.&Thoms بر(sustained repetitive firing) SRF نرون‌های پیرامیدال هیپوکامپ موش صحرایی را بررسی کردیم. بلوک SRF یکی از مکانیسم‌های پایه داروهای آنتی اپی‌لپتیک (AED) در سطح سلولی می‌باشد. اثر AF (mg/ml 6/0- 2/0) با یک داروی اولیه آزمایشی، فنی‌تویین (PHT) مقایسه شد. با استفاده از ...

Journal: Surgery and Trauma 2018

Abstract The aim of this study was to investigate the improvements of central serous chorioretinopathy (CSC) treated with topical dorzolamide. These observational case studies included nine eyes of the nine patients with CSC, treated by a physician with topical dorzolamide consecutively over a one-month period. The central macular thickness and best-corrected visual acuity (BCVA) were measured...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Dinakar Iyer David Chang Joe Marx Lei Wei Eric N Olson Michael S Parmacek Ashok Balasubramanyam Robert J Schwartz

Phosphorylation of a cluster of amino acids in the serum response factor (SRF) "MADS box" alphaI coil DNA binding domain regulated the transcription of genes associated with proliferation or terminal muscle differentiation. Mimicking phosphorylation of serine-162, a target of protein kinase C-alpha, with an aspartic acid substitution (SRF-S162D) completely inhibited SRF-DNA binding and blocked ...

Journal: :The Journal of biological chemistry 2014
Loka R K Penke Steven K Huang Eric S White Marc Peters-Golden

Differentiation of lung fibroblasts into contractile protein-expressing myofibroblasts by transforming growth factor-β1 (TGF-β1) is a critical event in the pathogenesis of pulmonary fibrosis. Transcription of the contractile protein α-smooth muscle actin (α-SMA) is mediated by the transcription factor serum-response factor (SRF) along with its co-activator, myocardin-related transcription facto...

Journal: :Current opinion in genetics & development 2004
Da-Zhi Wang Eric N Olson

Differentiation of smooth muscle cells (SMCs) is accompanied by the transcriptional activation of an array of muscle-specific genes that confer the unique contractile and physiologic properties of this muscle cell type. The majority of smooth muscle genes are controlled by serum response factor (SRF), a widely expressed transcription factor that also regulates genes involved in cell proliferati...

Journal: :Journal of cell science 2008
Stephan Busche Arnaud Descot Sylvia Julien Harald Genth Guido Posern

Epithelial cell-cell junctions are specialised structures connecting individual cells in epithelial tissues. They are dynamically and functionally linked to the actin cytoskeleton. Disassembly of these junctions is a key event during physiological and pathological processes, but how this influences gene expression is largely uncharacterised. Here, we investigate whether junction disassembly reg...

2017
Preeyachan Lourthai Patama Bhurayanontachai

Purpose To evaluate contrast sensitivity (CS) changes in acute central serous chorioretinopathy (CSC). Methods Visual acuity (VA), CS, and subretinal fluid (SRF) were evaluated monthly for 6 months. Treatment was considered at 3 months in case of persistent SRF. Results Twelve of 20 eyes (60%) had spontaneous SRF resolution within 4 months. Five of 8 patients with delayed SRF resolution rec...

Journal: :Environmental science & technology 2013
Costas A Velis Stuart Wagland Phil Longhurst Bryce Robson Keith Sinfield Stephen Wise Simon Pollard

Material flows and their contributions to fuel properties are balanced for the mechanical section of a mechanical-biological treatment (MBT) plant producing solid recovered fuel (SRF) for the UK market. Insights for this and similar plants were secured through a program of sampling, manual sorting, statistics, analytical property determination, and material flow analysis (MFA) with error propag...

Journal: :European journal of ophthalmology 2001
G Malukiewicz-Wiśniewska M Kotschy

PURPOSE To measure the vWF antigen concentration (vWF Ag) in subretinal fluid (SRF) and blood plasma. METHODS Prospective study of 30 patients, aged from 15 to 78 years (mean 52.7 years), undergoing retinal detachment surgery. Excluded were patients with venous or arterial disease or any other factors that could affect the parameters evaluated. Subretinal samples were obtained at the time of ...

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