Mutations in the Caenorhabditis elegans gene mec-8 were previously shown to cause defects in mechanosensation and in the structure and dye filling of certain chemosensory neurons. Using noncomplementation screens, we have identified eight new mec-8 alleles and a deficiency that uncovers the locus. Strong mec-8 mutants exhibit an incompletely penetrant cold-sensitive embryonic and larval arrest,...

Mucoepidermoid carcinoma (MEC) is a malignant neoplasms of the salivary glands which is rarely found in childhood. Its incidence rate has been reported to be 0.44 per 100,000.1 Most of them arise from the parotid gland (64 – 80%) while other locations that are less frequent include submandibular gland, sublingual gland, minor salivary glands and lacrimal gland.2 Submandibular gland cancer is ex...

The elimination of identified cells is a powerful tool for investigating development and system function. Here we report on genetically mediated cell disruption effected by the toxic Caenorhabditis elegans mec-4(d) allele. We found that ectopic expression of mec-4(d) in the nematode causes dysfunction of a wide range of nerve, muscle, and hypodermal cells. mec-4(d)-mediated toxicity is dependen...

The aim of the present study was to investigate the effect of realgar on the viability, proliferation and apoptosis in the human chronic lymphocytic leukemia (CLL) cell line, MEC‑1. Potential mechanisms mediating the effect were also explored in the experiment. Cultured MEC‑1 cells were incubated with various concentrations of realgar for 24, 48 and 72 h. A WST‑8 assay was employed to evaluate ...

Hippocampal neurons show a strong modulation by theta frequency oscillations. This modulation is thought to be important not only for temporal encoding and decoding of information in the hippocampal system, but also for temporal ordering of neuronal activities on timescales at which physiological mechanisms of synaptic plasticity operate. The medial entorhinal cortex (MEC), one of the two major...

It is now widely accepted that the entorhinal cortex (EC) plays a pivotal role in the processing of spatial information and episodic memory. The EC is segregated into two sub-regions, the medial EC (MEC) and the lateral EC (LEC) but a comprehensive understanding of their roles across multiple behavioral contexts remains unclear. Considering that it is still useful to investigate the impact of l...

Variable expressivity of mutant phenotypes in genetically identical individuals is a phenomenon widely reported but poorly understood. For example, mutations in the gene encoding the transcription factor ALR-1 in Caenorhabditis elegans result in variable touch receptor neuron (TRN) function. Using single-molecule in situ hybridization, we demonstrate that this phenotypic variability reflects en...

Methylation of cytosine (C) at C-phosphate-guanine (CpG) sites enhances reactivity of DNA towards electrophiles. Mutations at CpG sites on the p53 tumor suppressor gene that can result from these adductions are in turn correlated with specific cancers. Here we describe the first restriction-enzyme-assisted LC-MS/MS sequencing study of the influence of methyl cytosines (MeC) on kinetics of p53 g...

Damage caused by water shortages leads to physiological and biochemical changes in metabolism of plants and make them predispose to attack by pests and diseases and reduce the quality of the crops. In order to evaluate the effect of supplemental irrigation on safflower fly (A. helianthi) population of safflower cultivars, an experiment conducted as a split plot based on randomized complete bloc...

In this paper, we present the design, implementation and evaluation of a new distributed shared memory (DSM) coherence model called multiple-writer entry consistency (MEC). MEC combines the eecient communication mechanisms of Lazy Release Consistency (LRC) with the exible data management of the Shared Regions 17, 11] and Entry Consistency (EC) models 5]. This is achieved in MEC by decoupling sy...