Bacterial insertion sequences (ISs) are the simplest kinds of bacterial mobile DNA. Evolutionary studies need consistent IS annotation across many different genomes. We have developed an open-source software package, IScan, to identify bacterial ISs and their sequence elements--inverted and target direct repeats--in multiple genomes using multiple flexible search parameters. We applied IScan to...

Submitted for publication: September 10, 2009 Accepted for publication: January 5, 2010 The adoption in 2000 of the Common Technical Document (CTD) format for marketing applications notwithstanding, the US regulations requiring an integrated summary of effectiveness (ISE) and an integrated summary of safety (ISS) remain in effect. Many applicants, however, have attempted to use the CTD module 2...

Objective. Retrospective single-centre analysis of growth characteristics in 182 healthy short children born small for gestational age (SGA) or appropriate for gestational age (idiopathic short stature, ISS). Methods. Birth size references from the USA and Sweden were compared, and for the classification as SGA or ISS the Swedish reference was chosen. Height, target height (TH), bone age (BA), ...

Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases. The enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) add and remove O-GlcNAc, but the mechanisms regulating their expression remain unclear. Here, we demonstrate that retention of the fourth intron of OGT is regulated in response to O-GlcNAc leve...

In this paper, we study input-to-state stability (ISS) of an equilibrium for a scalar conservation law with nonlocal velocity and measurement error arising in highly re-entrant manufacturing system. By using suitable Lyapunov function, prove sufficient necessary conditions on ISS. We propose numerical discretization the error. A discrete function is analyzed to provide ISS proposed approximatio...

OBJECTIVE To investigate the effect of in situ simulation (ISS) versus off-site simulation (OSS) on knowledge, patient safety attitude, stress, motivation, perceptions of simulation, team performance and organisational impact. DESIGN Investigator-initiated single-centre randomised superiority educational trial. SETTING Obstetrics and anaesthesiology departments, Rigshospitalet, University o...

BACKGROUND In critical injury, the occurrence of increased oxidative stress or a reduced antioxidant status has been observed. The purpose of this study was to correlate the degree of oxidative stress, by measuring the oxidation-reduction potential (ORP) of plasma in the critically injured, with injury severity and serum amyloid A (SAA) levels. METHODS A total of 140 subjects were included in...

We present a general approach to analyzing stability of hybrid systems, based on input-to-state stability (ISS) and small-gain theorems. We demonstrate that the ISS small-gain analysis framework is very naturally applicable in the context of hybrid systems. Novel Lyapunovbased and LaSalle-based small-gain theorems for hybrid systems are presented. The reader does not need to be familiar with IS...

The Erasmus User Centre, located at ESTEC in Noordwijk, will have overall responsibility for the preparation and execution of operations for the European Drawer Rack (EDR) facility in the European Columbus laboratory on the International Space Station (ISS). Together with the national User Support and Operations Centres (USOCs) involved in the operation of experiments on the ISS, it will form t...

Two experiments (EXPs) were conducted to evaluate models of immune system stimulation (ISS) that can be used in nutrient metabolism studies in growing pigs. In EXP I, the pig's immune response to three non-pathogenic immunogens was evaluated, whereas in EXP II the pig's more general response to one of the immunogens was contrasted with observations on non-ISS pigs. In EXP I, nine growing barrow...