نتایج جستجو برای: ژن fasn
تعداد نتایج: 16725 فیلتر نتایج به سال:
BACKGROUND IDEFICS (Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects in Children and Infants Project) is a European multicenter study on childhood obesity. One of its goals is to define early biomarkers of risk associated with obesity and its comorbid conditions. OBJECTIVE We considered blood cells as a new potential source of transcriptional biomarkers for these...
25 To determine the effects of age and lipoic acid supplementation on hepatic gene 26 expression, we fed young (3 months) and old (24 months) male Fischer 344 rats a diet with 27 or without 0.2% (w/w) R-α-lipoic acid (LA) for two weeks. Total RNA isolated from liver 28 tissue was analyzed by Affymetrix microarray to examine changes in transcriptional profiles. 29 Results showed elevated pro-inf...
Abstract Radiation therapy (RT) is the standard-of-care for glioblastoma (GBM) and only treatment inoperable brain tumors. In multiple cancer, RT stimulates anti-tumor immunity by at least activating cancer cell-intrinsic type I interferon (IFN-I) responses. However, GBM inevitably recur, suggesting that promotes immune evasion mechanisms. Altered fatty acid (FA) metabolism an emerging mechanis...
Cyclic AMP Response Element-Binding Protein 1 (Creb1) is a transcription factor that mediates cyclic adenosine 3', 5'-monophosphate (cAMP) signalling in many tissues. Creb1(-/-) mice die at birth due to respiratory failure and previous genome-wide microarray analysis of E17.5 Creb1(-/-) fetal mouse lung identified important Creb1-regulated gene targets during lung development. The lipogenic enz...
Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR). Activating transcription factor 6 (ATF6), one of three main UPR sensors, functions to both promote FLD during acute stress and reduce FLD during chronic stress. There is little mechanistic understandin...
Dietary PUFAs (polyunsaturated fatty acids) co-ordinately suppress transcription of a group of hepatic genes encoding glycolytic and lipogenic enzymes. Suppression of Fasn (fatty acid synthase) transcription involves two PUFA-responsive regions, but the majority of PUFA sensitivity maps to a region within the proximal promoter containing binding sites for NF-Y (nuclear factor-Y), Sp1 (stimulato...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید