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تعداد نتایج: 15984 فیلتر نتایج به سال:
The human dimension of the Columbian Exchange entailed substantial genetic admixture between ancestral source populations from Africa, the Americas and Europe, which had evolved separately for many thousands of years. We sought to address the implications of the creation of admixed American genomes, containing novel allelic combinations, for human health and fitness via analysis of an admixed C...
The geographic origin and time of dispersal of Austroasiatic (AA) speakers, presently settled in south and southeast Asia, remains disputed. Two rival hypotheses, both assuming a demic component to the language dispersal, have been proposed. The first of these places the origin of Austroasiatic speakers in southeast Asia with a later dispersal to south Asia during the Neolithic, whereas the sec...
Heterozygous germline mutations in p63, a transcription factor of the p53 family, result in abnormal morphogenesis of the skin and its associated structures, including hair follicles and teeth. In mice lacking p63, all ectodermal organs fail to develop, and stratification of the epidermis is absent. We show that the ectodermal placodes that mark early tooth and hair follicle morphogenesis do no...
Hair and teeth are appendages of ectodermal origin, and there are common molecular backgrounds involved in their formation. To date, it has been revealed that a non-synonymous polymorphism in EDAR has effects on the morphological variation in both hair and teeth. Previous association studies have confirmed that single-nucleotide polymorphisms (SNPs) in/near THADA, FRAS1, WNT10A, NAF1 and FGFR2 ...
The developing submandibular salivary gland (SMG) is a well-studied model for tissue interactions and branching morphogenesis. Its development shares similar features with other ectodermal appendages such as hair and tooth. The ectodysplasin (Eda) pathway is essential for the formation and function of several ectodermal organs. Mutations in the signaling components of the Eda pathway lead to a ...
زمینه و هدف: در سال‌های اخیر تکنیک‌های جدیدی برای تشخیص چهره و ساختار جمجمه، با روش‌های ژنتیکی مولکولی، برای استفاده در موارد قانونی و جنایی پیشنهاد شده است که بررسی خصوصیات فردی، همچون رنگ چشم، مو و پوست را میسر ساخته است. فناوری تشخیص چهره با DNA، به بررسی مارکرهای مولکولی مؤثر در تشخیص چهره و جمجمه با استفاده از فناوری‌های تعیین توالی کل یا بخشی از ژنوم می‌پردازد. روش بررسی: برای تشخیص اند...
Konsumen membutuhkan perlindungan konsumen karena masalah yang mempengaruhi keselamatan, keamanan, dan kesehatan fisik mental mereka. Suatu barang dianggap ilegal jika melanggar atau dilarang oleh undang-undang. Penelitian” bertujuan untuk memperjelas seperti apa pengawasan perlindungan” penggunaan produk obat-obatan terlarang, peran Kantor Kabupaten Nias Selatan dalam penertiban terlarang ileg...
BACKGROUND Dental agenesis is the most common, often heritable, developmental anomaly in humans. Mutations in MSX1, PAX9, AXIN2 and the ectodermal dysplasia genes EDA, EDAR and EDARADD have been detected in familial severe tooth agenesis. However, until recently, in the majority of cases (∼90%) the genetic factor could not be identified, implying that other genes must be involved. Recent insigh...
An outstanding question in human genetics has been the degree to which adaptation occurs from standing genetic variation or from de novo mutations. Here, we combine several common statistics used to detect selection in an Approximate Bayesian Computation (ABC) framework, with the goal of discriminating between models of selection and providing estimates of the age of selected alleles and the se...
During organogenesis, cell fate specification and patterning are regulated by signaling centers, specialized clusters of morphogen-expressing cells. In many organs, initiation of development is marked by bud formation, but the cellular mechanisms involved are ill defined. Here, we use the mouse incisor tooth as a model to study budding morphogenesis. We show that a group of nonproliferative epi...
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