Cyclosporine A (CsA) inhibits P-glycoprotein (Pgp)-mediated cellular export of anthracyclines at clinically achievable concentrations. This randomized controlled trial was performed to test the benefit of CsA addition to treatment with cytarabine and daunorubicin (DNR) in patients with poor-risk acute myeloid leukemia (AML). A total of 226 patients were randomly assigned to sequential treatment...

stroke and is, as mentioned previously, associated with a bad prognosis. However, idiopathic CSA is observed in those without any comorbidities and is not necessarily periodic in nature. Moreover, there are no data indicating that the presence of idiopathic or postarousal CSA by itself is a poor prognostic marker for patients, and no consensus on when and how it should be treated. In view of th...

Plasma and aqueous levels of cyclosporin A (CsA) were determined following topical administration of CsA 1% to healthy rabbit eyes and compared with levels obtained when administered to rabbit eyes which had received corneal grafts 7-10 days previously. In addition plasma levels were determined following intramuscular administration of 50 mg CsA and the results compared with those obtained foll...

Acute cyclosporin A (CsA) treatment inhibits mitochondrial respiration, yet effects of chronic treatment remain unclear. Accordingly, the effects of chronic CsA on oxygen metabolism in perfused rat liver and isolated mitochondria were investigated. Basal rates of oxygen uptake of around 120 micromol/g/h in isolated perfused livers from vehicle-treated controls were elevated about 1.6-fold by ch...

Cyclosporine (CsA) is a potent immunosuppressant used in the prevention of transplanted organ rejection. CsA is associated with sodium retention, hypertension, hyperkalemia, interstitial fibrosis, and progressive renal failure in transplant recipients. The cellular mechanisms, responding to these complications, were revealed in recent studies. CsA decreased the expression iNOS and production of...

INTRODUCTION Childhood sexual abuse (CSA) has been a topic of interest in sexual health research for decades, yet literature on the sexual health correlates of CSA has been hindered by methodologic inconsistencies that have resulted in discrepant samples and mixed results. AIM To review the major methodologic inconsistencies in the field, explore the scientific and clinical impact of these in...

stroke and is, as mentioned previously, associated with a bad prognosis. However, idiopathic CSA is observed in those without any comorbidities and is not necessarily periodic in nature. Moreover, there are no data indicating that the presence of idiopathic or postarousal CSA by itself is a poor prognostic marker for patients, and no consensus on when and how it should be treated. In view of th...

OBJECTIVE This paper examined the relationship between exposure to sexual and physical abuse (CSA and CPA) in childhood and later educational achievement outcomes in late adolescence and early adulthood in a birth cohort of over 1,000 children studied to age 25. METHOD Retrospective data on CSA and CPA were gathered at ages 18 and 21 and used to form a best estimate of exposure to CSA and CPA...

RATIONALE AND OBJECTIVES Pulmonary vascular alteration is one of the characteristic features of chronic obstructive pulmonary disease (COPD). Recent studies suggest that vascular alteration is closely related to endothelial dysfunction and may be further influenced by emphysema. However, the relationship between morphological alteration of small pulmonary vessels and the extent of emphysema has...