نتایج جستجو برای: ژنهای cyp17 و srd5a2

تعداد نتایج: 761262  

Journal: :Cancer research 2001
R McKean-Cowdin H S Feigelson M C Pike G A Coetzee L N Kolonel B E Henderson

Common variants among genes coding for enzymes in sex steroid biosynthetic pathways may influence the risk of endometrial cancer. We examined the association between endometrial cancer risk and estrogen replacement therapy (ERT) by CYP17 genotype using 51 incident cases and 391 randomly selected controls from a multiethnic cohort in Hawaii and Los Angeles, California. The relative risk of endom...

2010
Bingbing Wei Yunyun Zhang Bo Xi Junkai Chang Jinming Bai Jiantang Su

OBJECTIVE The cytochrome P450 17α-hydroxylase (CYP17) plays a vital role in androgen biosynthesis. A T-to-C polymorphism in the 5' promoter region of CYP17 has been implicated as a risk factor for prostate cancer, but the results of individual studies are inconclusive or controversial. To derive a more precise estimation of the relationship, we performed an updated meta-analysis from 31 studies...

Journal: :Hong Kong medical journal = Xianggang yi xue za zhi 2009
Angel O K Chan Betty W M But Gene T C Lau Almen L N Lam K L Ng Y Y Lam C Y Lee C C Shek

5Alpha-reductase 2 deficiency is an autosomal recessive disorder characterised by lack of masculinisation in XY individuals due to failure to convert testosterone to dihydrotestosterone, the bioactive androgen. Traditionally, the testosterone-to-dihydrotestosterone ratio is used to diagnose this condition but interpreting these results is not always straightforward, thus they may be inconclusiv...

2014
Mark N Stein Neal Patel Alexander Bershadskiy Alisa Sokoloff Eric A Singer

Suppression of gonadal testosterone synthesis represents the standard first line therapy for treatment of metastatic prostate cancer. However, in the majority of patients who develop castration-resistant prostate cancer (CRPC), it is possible to detect persistent activation of the androgen receptor (AR) through androgens produced in the adrenal gland or within the tumor itself. Abiraterone acet...

2017
Aleksandra Rył Iwona Rotter Anna Grzywacz Iwona Małecka Karolina Skonieczna-Żydecka Katarzyna Grzesiak Marcin Słojewski Aleksandra Szylińska Olimpia Sipak-Szmigiel Małgorzata Piasecka Kinga Walczakiewicz Maria Laszczyńska

Introduction: The etiology of benign prostatic hyperplasia (BPH) has not so far been fully explicated. However, it is assumed that changes in the levels of hormones associated with aging can contribute to the development of prostatic hyperplasia. Dihydrotestosterone combines with the androgen receptor (AR) proteins of the prostate gland. Enzyme activity is based on two isoenzymes: type 1 and ty...

Journal: :Arquivos brasileiros de endocrinologia e metabologia 2008
Regina M Martin Paulo S L Oliveira Elaine M F Costa Ivo J P Arnhold Berenice B Mendonca

Combined 17alpha-hydroxylase/17,20-lyase deficiency is a rare, autosomal recessive form of congenital adrenal hyperplasia characterized by the coexistence of hypertension, caused by the hyperproduction of mineralocorticoid precursors and DSD in males and sexual infantilism in females, due to impaired production of sex hormones. Several CYP17 mutations resulting in 17alpha-hydroxylase/17,20-lyas...

2005
Julie A. Douglas Kimberly A. Zuhlke Jennifer Beebe-Dimmer Albert M. Levin Stephen B. Gruber David P. Wood Kathleen A. Cooney

Polymorphisms in genes that code for enzymes or hormones involved in the synthesis and metabolism of androgens are compelling biological candidates for prostate cancer. Four such genes, CYP17 , CYP19 , CYP11A1 , and LH-b , are involved in the synthesis and conversion of testosterone to dihydrotestosterone and estradiol. In a study of 715 men with and without prostate cancer from 266 familial an...

Journal: :Polish journal of pathology : official journal of the Polish Society of Pathologists 2009
Anna Sobczuk Hanna Romanowicz Tomasz Fiks Ireneusz Połać Beata Smolarz

The cytochrome P450 family (CYPs) enzymes play an important role in the metabolism of environmental carcinogens and of oestrogen and can affect breast cancer risk. We hypothesise that polymorphisms of CYP17 and CYP19 gene can predict higher incidence of breast cancer. In the present work the distribution of genotypes and frequency of alleles of the T/C polymorphism in promoter region of CYP17 a...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه علم و فرهنگ - پژوهشکده رویان 1389

هدف این مطالعه بررسی اثر سیستم هم کشتی با سلولهای گرانولوزا مورال بر بلوغ توده های coc گوسفند بوده است، همچنین مراحل بلوغ هسته و سطح بیان ژنهای بلوغ و رسپتورهای آنها در دو مرحله ژرمینال وزیکول (gv) و متافاز دوم (mii) ارزیابی شد. توده های coc جدا شده از تخمدان بطور تصادفی به چهار گروه تقسیم شدند: در گروههای کنترل توده های coc به ترتیب بمدت 3 و 27 ساعت در محیط بلوغ قرار گرفتند (3h control and 27h...

2010
Luay A. Ali

صخلملا Seasonal variation of zooplankton biomass has been carried out at two selected sites on Greater Zab River. Monthly samples of water were collected during period from January to December 2008. Some physico-chemical properties of water were studied including water temperature (from 8 to 30.5 C), hydrogen ion concentration (from 6.3 to 8), EC (from 255 to 821 μs.cm), turbidity (1085 NTU), d...

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