CD52 is a phosphatidylinositolglycan (PIG)-anchored glycoprotein (PIG-AP) expressed on normal T and B lymphocytes, monocytes, and the majority of B-cell non-Hodgkin lymphomas. We observed the emergence of CD52- T cells in 3 patients after intravenous treatment with the humanized anti-CD52 monoclonal antibody Campath-1H for refractory B-cell lymphoma and could identify the underlaying mechanism....

The second step in glycosylphosphatidylinositol biosynthesis is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) catalyzed by N-acetylglucosaminylphosphatidylinositol deacetylase (PIG-L). Previous studies of mouse thymoma cells showed that GlcNAc-PI de-N-acetylase activity is localized to the endoplasmic reticulum (ER) but enriched in a mitochondria-associated ER mem...

This study was carried out between January and April 2008 with 14 caregivers of children younger than 5 years residing in Tizimín city, Mexico. It aimed to understand the social representations of eating and the Programa Oportunidades [Opportunity Program] held by caregivers taking into account their social and cultural context. This qualitative investigation with an ethnographic approach was b...

Records on 47,360 Yorkshire, 28,762 Landrace, 14,020 Duroc, and 9,983 Hampshire pigs for backfat depth and days to 100 kg made between 1989 and 1992 in herds on the Ontario Swine Improvement Program (OSIP) were used to estimate additive genetic (animal), common environmental (litter), and residual variances and covariances of the two traits. Analysis was by the DFREML program of K. Meyer using ...

The District also could adopt the idea of police mini-stations and youth safe havens, which share the same space and have worked well in places as diverse as Columbia, S.C., New Hampshire and San Juan, Puerto Rico. Police in these ministations become an integral part of the inner-city community and function as mentors for young people as well as law officers. The safe havens, run by civilian no...