Blockchain-based IoT systems can manage devices and achieve a high level of data integrity, security, provenance. However, incorporating existing consensus protocols in many limits scalability leads to computational cost latency. In addition, location-centric characteristics applications paired with limited storage computing power bring about more limitations, primarily due the location-agnosti...

Membrane rafts are transient and unstable membrane microdomains that are enriched in sphingolipids, cholesterol, and specific proteins. They are involved in intracellular trafficking, signal transduction, pathogen entry, and attachment of various ligands. Increasing experimental evidence on the crucial biological roles of membrane rafts under normal and pathological conditions require new techn...

Reversible modifications of reversible addition–fragmentation chain transfer (RAFT)-polymerization derived end groups are usually limited to reductive degradable disulfide conjugates. However, self-immolative linkers can promote ligation and traceless release primary secondary amines as well alcohols via carbonates or carbamates in ?-position disulfides. In this study, these two strategies comb...

This paper describes how an existing application may be integrated into the RaFT system to provide enhanced fault-tolerance. Some fault-tolerance is provided transparently using hardware voting, but the RaFT system is in principle able to do more by exploiting reconfiguration. The example application is a simplified railway signalling system and a pipeline of transputers has been selected as th...

Approaches to the synthesis of block copolymers containing organic semiconductor segments (polythiophene, perylene diimide) by RAFT polymerization have been explored. A method involving transformation of a vinyl derivative to a macro-RAFT agent provides for the synthesis of block copolymers which are joined by a short non-hydrolysable linkage.

Methods We assessed the relationships between species-level traits (habitat use, position in water column, diet, body size, schooling activity) and rafting behaviour among 985 species of reef fish using generalized linear mixed-effect modelling. To assess whether the relationships between rafting behaviour and species traits were mediated by raft type, our analysis included interactions between...

Hydrophilic polymers were attached to lysozyme by a combination of grafting-to and grafting-from approaches using RAFT polymerization. A hydrophilic oligomer was synthesized, and attached to the protein. The protein-oligomer hybrid contained the RAFT end group, enabling chain extension in solution. Lysozyme maintained activity throughout this process.

We explore a kinetically controlled strategy to suppress the gelation in the homopolymerization of multi-vinyl monomers (MVMs) via RAFT polymerization. We report the generation of 3D single cyclized polymer structures from the RAFT process, which significantly contradicts the classic F-S theory. This approach enables synthesis of a new generation of nanosize macromolecular architectures.

P-selectin glycoprotein ligand-1 (PSGL-1) and integrins are adhesion molecules that play critical roles in host defense and innate immunity. PSGL-1 mediates leukocyte rolling and primes leukocytes for integrin-mediated adhesion. However, the mechanism that PSGL-1 as a rolling receptor in regulating integrin activation has not been well characterized. Here, we investigate the function of lipid r...

Triglyceride-rich lipoprotein (TGRL) lipolysis may provide a proinflammatory stimulus to endothelium. Detergent-resistant plasma membrane microdomains (lipid rafts) have a number of functions in endothelial cell inflammation. The mechanisms of TGRL lipolysis-induced endothelial cell injury were investigated by examining endothelial cell lipid rafts and production of reactive oxygen species (ROS...