Dendritic cells (DCs) are pivotal in the development of specific T-cell responses to control pathogens, as they govern both the initiation and the polarization of adaptive immunity. To investigate the capacities of migrating DCs to respond to pathogens, we used physiologically generated lymph DCs (L-DCs). The flexible polarization of L-DCs was analysed in response to Salmonella or helminth secr...

BACKGROUND Dendritic cells (DCs) are professional antigen-presenting cells that have multiple subpopulations with different phenotypes and immune functions. Previous research demonstrated that DCs have strong potential for anti-viral defense in the host. However, viruses including alphaherpesvirinae have developed strategies to interfere with the function or maturation of DCs, causing immune dy...

Two-dimensional (2D) cell culture systems are normally used for in vitro experiments. These have some drawbacks which affect results of experiments because cultured cells different morphology and physiological properties comparing to vivo models. Therefore, there current technique develop three-dimensional (3D) closer the environment real tissues. In our study, we polycaprolactone fiber scaffol...

Aged subjects display increased susceptibility to mucosal diseases. Retinoic Acid (RA) plays a major role in inducing tolerance in the mucosa. RA acts on Dendritic cells (DCs) to induce mucosal tolerance. Here we compared the response of DCs from aged and young individuals to RA with a view to understand the role of DCs in age-associated increased susceptibility to mucosal diseases. Our investi...

Many developing countries (DCs) are currently spending on construction projects due to the high demand resulting from rapid urbanization. However, results of these in terms time, cost, and quality do not tend meet expectations stakeholders. Despite relevance visibility this situation many DCs, topic has received little research attention. This study examines combined effect six factors that com...

Distribution centres are becoming more and relevant for spatial planning, due to their rapidly increasing size number. There is little literature, however, that provides a generalized analysis of the functional attributes distribution centres, none discusses relationships between these attributes. Our aim fill this gap by providing new evidence understand relationship. We make use an extensive ...

Lung dendritic cells (DCs) are difficult to study due to their limited quantities and the complexities required for isolation. Although many procedures have been used to overcome this challenge, the effects of isolation techniques on lung DCs have not been reported. The current study shows that freshly isolated DCs (CD11c+) have limited ability to induce proliferation in allogeneic T cells, and...

Dendritic cells (DCs) are potent antigen-presenting cells that can activate quiescent T lymphocytes. When pulsed with tumor-associated antigen (TAA) peptide or protein, murine DCs can provide antitumor immunity. We reasoned that DCs retrovirally transduced with TAA genes might have important advantages over peptide- or protein-pulsed DCs, including long-term TAA presentation in vivo, and presen...