نتایج جستجو برای: پروتیین p24
تعداد نتایج: 3021 فیلتر نتایج به سال:
Point-Of-Care p24 Infant Testing for HIV May Increase Patient Identification despite Low Sensitivity
The long delay in returning test results during early infant diagnosis of HIV (EID) often causes loss-to-follow-up prior to antiretroviral treatment (ART) initiation in resource-limited settings. A point-of-care (POC) test may help overcome these challenges. We evaluated the performance of the LYNX p24 Antigen POC test in Mozambique. 879 HIV-exposed infants under 18 months of age were enrolled ...
Infection of HIV-1-transgenic mice with Mycobacterium avium, a common opportunistic pathogen in AIDS patients, was shown to result in increased tissue expression of viral specific transcripts. Moreover, by coculturing splenocytes from the transgenic animals with human T cells it was possible to demonstrate that the elevation in HIV-1 mRNA triggered by M. avium infection reflects increased produ...
با توجه به تفاوت فاحش، در تعداد پروتیین های گزارش شده در نمایۀ دوبعدی پروتئوم اشک (97 تا 250 پروتیین)، و همچنین با در نظر گرفتن ناهمگون بودن محتوای پروتیینی این نمونه، تصور بر آن است که عدم انحلال صحیح، عاملی مهم در ناکارآمدی بررسی های الکتروفورتیک اشک باشد. بدیهی است که دستیابی به الگوی جداسازی مطلوب تنها در سایۀ حفظ حالت محلول پروتیین ها و جلوگیری از رسوب آن ها در مراحل مختلف، حاصل می گردد. م...
هدف از این تحقیق بررسی اثرات جایگزینی آرد ماهی با منابع پروتیین گیاهی در سطوح بالا بر شاخص‌های رشد، کارایی تغذیه‌ای، ترکیب شیمیایی و ترکیب اسیدهای چرب بافت عضله ماهی قزل آلای رنگین کمان می‌باشد. 700 عدد ماهی با وزن متوسط 2±15 گرم انتخاب و در داخل 12 تانک (300 لیتری) با تراکم 50 عدد در هر تانک نگه داری و به مدت 60 روز با جیر...
We prepared a probe of radiolabeled, glutaraldehyde cross-linked filamentous actin (F-actin) to study binding of actin to membranes of Dictyostelium discoideum. The probe bound to membranes or detergent extracts of membranes with a high affinity and in a saturable manner. The binding could be reduced by boiling of either the actin probe or the membranes, or by addition of excess native F-actin,...
We evaluated a low-cost virological failure assay (VFA) on plasma and dried blood spot (DBS) specimens from HIV-1 infected patients attending an HIV clinic in Harare. The results were compared to the performance of the ultrasensitive heat-denatured p24 assay (p24). The COBAS AmpliPrep/COBAS TaqMan HIV-1 test, version 2.0, served as the gold standard. Using a cutoff of 5,000 copies/mL, the plasm...
The VIDAS HIV DUO Ultra, a fourth-generation immunoassay under development for the simultaneous detection of human immunodeficiency virus type 1 (HIV-1) p24 antigen and antibodies to HIV-1 and HIV-2, was evaluated. The enzyme-linked fluorescence immunoassay, performed on the automated VIDAS instrument, is claimed to detect early and established HIV infection. The assay was challenged with a tot...
Many B cell epitopes within p24 of human immunodeficiency virus type 1 (HIV-1) were identified, while most of them were determined by using murine monoclonal antibodies reacting with overlapping peptides of p24. Therefore these epitopes may not represent the actual epitopes recognized by the HIV-1 infected individuals. In the present study, immune responses of 67 HIV-1 positive sera from Yunnan...
Diadenosine 5',5'''-P1,P2-diphosphate (Ap2A) is one of the adenylic dinucleotides stored in platelet granules. Along with proaggregant ADP, it is released upon platelet activation and is known to stimulate myocyte proliferation. We have previously demonstrated synthesis of Ap2A and of two isomers thereof, called P18 and P24, from their high pressure liquid chromatography retention time, by the ...
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