The aim of the present study was to determine whether specific subgroups of schizophrenic patients, grouped according to electrodermal characteristics, show differences in the N-acetylaspartate/creatine plus choline (NAA / (Cr + Cho)) ratios in the frontal, cingulate and perirolandic cortices. Skin conductance levels (SCL) and skin conductance responses to auditory stimulation were measured in ...

Sclerostin is a circulating osteocyte-derived glycoprotein that negatively regulates Wnt-signaling after binding the LRP5/LRP6 co-receptors. Pharmacologic sclerostin inhibition produces bone anabolic effects after spinal cord injury (SCI), however, the effects of sclerostin-antibody (Scl-Ab) on muscle morphology remain unknown. In comparison, androgen administration produces bone antiresorptive...

The SCL/TAL-1 gene encodes a basic helix-loop-helix transcription factor that is expressed in multipotent hematopoietic progenitors before lineage commitment. Its expression is maintained during differentiation along erythroid, mast, and megakaryocytic lineages, but is repressed after commitment to nonexpressing lineages. To begin to address the molecular mechanisms underlying this complex patt...

Sclerostin antibody (Scl-Ab) represents a promising therapeutic approach to treat patients with osteoporosis. PURPOSE The aim of this study was to investigate the effects of Scl-Ab, running and a combination of both on bone formation. METHODS Sixty female Wistar rats, aged 8 months were randomly assigned to five groups (subcutaneous injections performed twice a week): (1) (Sham): sedentary ...

The mechanisms underlying maintenance of hematopoietic stem cells (HSCs) remain one of the critical mysteries in blood development. Because of advances in whole genome analysis and in reverse genetic animal model systems, there has been accelerating progress in identification of the genes involved in stem cell selfrenewal, lineage commitment and differentiation, and cell-cycle regulation. Criti...

Forty-three anxiety disorder patients (DSM-III) who completed the Hopkins Symptom Checklist (SCL-90-R) and a caffeine questionnaire were compared to 124 medical inpatients. Eighty-four percent of the anxious patients were low caffeine consumers (0-249 mg/day) compared to 41% of medical inpatients; 65% of anxiety patients consumed less than 100 mg/day. In anxiety patients, there were no signific...