3-Arylhydrazono-2,4-dioxo-4-phenylbutanoateshave been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides.Reactions ofthe 3-arylhydrazono-2,4-dioxo-4-phenylbutanoateswith 1-aminoguanidine, semicarbazide, and thiosemicarbazidegave5-substituted 2-imino-6-azauracil (3a),6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds - IR, 1H...

Formation of the mitochondrial membrane potential (DY) depends on flux of respiratory substrates, ATP, ADP, and Pi through voltage-dependent anion channels (VDAC). As tubulin promotes single-channel closure of VDAC, we hypothesized that tubulin is a dynamic regulator of DY, which in cultured cancer cells was assessed by confocal microscopy of the potential-indicating fluorophore tetramethylrhod...

3,5-Bis(4-chlorobenzylidene)-1-ethylpiperidin-4-one (1b) was condensed with malononitrile or cyanothioacetamide to yield pyranopyridine 2 and thiopyridopyridine 3b, respectively. Treatment of compound 3b with methyl iodide or ethyl chloroacetate in the presence of a base catalyst gave the corresponding compounds 4 and 5. Compound 3b was reacted with 2-chloro-N-arylacetamide derivatives to yield...

Five novel antibiotics described as irpexans (1, 2, 3a, 3b, 4) were isolated from fermentations of an Irpex species in the course of a screening for new inhibitors of AP-1 and NF-kappaB mediated signal transduction pathways in COS-7 cells using secreted alkaline phosphatase (SEAP) as a reporter gene. The expression of an AP-1 and NF-kappaB driven SEAP reporter gene was inhibited in a dose depen...

Disclosures: M.C. Mendoza: None. K. Sonn: None. S.S. Bellary: None. A. Kannan: None. G. Singh: None. C. Park: None. S.R. Stock: None. E.L. Hsu: 2; Medtronic, Stryker, Pioneer Surgical, Globus, SpineSmith, Lifenet, AONA, Synthes/DePuy, Bioventus. 3B; Stryker, Zimmer, Medtronic, Pioneer Surgical, Terumo, Spinesmith. W. Hsu: 2; Medtronic, Stryker, Pioneer Surgical, Globus, SpineSmith, Lifenet, AON...

This paper presents two new filtering operators for numerical CSPs (systems with constraints over the reals) based on constructive disjunction, as well as a new splitting heuristic. The fist operator (CID) is a generic algorithm enforcing constructive disjunction with intervals. The second one (3BCID) is a hybrid algorithm mixing constructive disjunction and shaving, another technique already u...

A number of bis Schiff′s bases 3a-d have been synthesized by condensation of 2,4,8,10 tetraoxaspiro[5,5]undecane 3,9dipropanamine 1 with furfural, indole-3-aldehyde, 2-acetylpyridine, 4-acetylpyridine and 5a-c by condensation of 1,4-bis (3-aminopropyl) piperazine 4 with indole-3-aldehyde, 2-acetylpyridine, 4-acetylpyridine, in high yields by using microwave irradiation. Bis hydrazone derivative...

Arc-consistency algorithms are widely used to simplify Constraint Satisfaction Problems. The new notion of a double-support check is presented to improve the average performance of arc-consistency algorithms. The improvement is that, where possible, consistencychecks are used to find supports for two values, one value in the domain of each variable, which were previously known to be unsupported...