Background: Delays in diagnosis and treatment have been reported for many cancers, with resultant stage migration worse survival; however, few data exist patients hepatocellular carcinoma (HCC). These are of particular importance light the COVID-19 pandemic, which has caused disruptions healthcare processes may continue to impact cancer care foreseeable future. The aim our study was characteriz...

Background and AimsStress granules (SGs) as membrane-less cytoplasmic foci formed in response to unfavorable external stimuli could promote cancer cells adapt hostile environments. Hepatocellular carcinoma (HCC) is prone be highly aggressive once diagnosed, which markedly reduces patient survival time. Therefore, it crucial develop valid diagnostic markers prognosticate HCC prognosis, promotes ...

BACKGROUND Many studies have suggested that the immune response may play a crucial role in the progression of hepatocellular carcinoma (HCC). Therefore, our aim was to establish a (i) functional culture of primary human tumor hepatocytes and non-tumor from patients with hepatocellular carcinoma (HCC) and (ii) a co-culture system of HCC and non-HCC hepatocytes with autologous peripheral blood mo...

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. In the last few decades, there has been a marked increase in therapeutic options for HCC and epidemiological characteristics at HCC diagnosis have also significantly changed. With these changes and advances in medical technology and surveillance program for detecting earlier stage HCC, surviva...

BACKGROUND/AIMS Cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are up-regulated in hepatocellular carcinoma (HCC). To investigate the levels of COX-2 and VEGF expression in chronic hepatitis (CH), cirrhosis, and HCC. METHODS The immunohistochemical expressions of COX-2 and VEGF were evaluated in tissues from patients with CH (n=95), cirrhosis (n=38), low-grade HCC (LG-...

Although sphingosine 1-phosphate (S1P) has been reported to play an important role in cancer pathophysiology, little is known about S1P and hepatocellular carcinoma (HCC). To clarify the relationship between S1P and HCC, 77 patients with HCC who underwent surgical treatment were consecutively enrolled in this study. In addition, S1P and its metabolites were quantitated by LC-MS/MS. The mRNA lev...

Current treatment of HCC is based on the updated Barcelona algorithm [3]. According to this algorithm, therapeutic options for HCC are divided into curative treatments (resection, liver transplantation and radiofrequency/percutaneous ethanol injection) for HCC in very early stage or early stage (A), transarterial chemoembolization (TACE) for intermediate stage (B) HCC, sorafenib for advanced st...

BACKGROUND The number of patients with hepatocellular carcinoma (HCC) in the absence of both hepatitis B virus surface antigen (HBsAg) and hepatitis C virus antibody (HCVAb) (NBNC-HCC) has been rapidly increasing in Japan. The objective of this study was to compare the clinical and pathological characteristics between patients with the NBNC-HCC, those with HBsAg positive HCC (B-related HCC) and...