Clinical studies have demonstrated that some antihypertensive agents provide renoprotection independent of BP lowering. Recent in vitro and in vivo studies evaluated the mechanisms involved in this protection. First, the in vitro effects of several angiotensin II type 1 receptor blockers (ARB), calcium channel blockers (CCB), and beta blockers (BB) on various mediators were compared: Formation ...

Background. Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II type 1 receptor blockers (ARB) decrease cardiovascular mortality and slow the progression of renal disease in non-transplant patients, but their impact on kidney transplant outcome has not been well established.Methods. Patients receiving a renal allograft in Spain in 1990, 1994, 1998 and 2002 were considered for the...

PURPOSE Autosomal recessive bestrophinopathy (ARB) is a retinal dystrophy affecting macular and retinal pigmented epithelium function resulting from homozygous or compound heterozygous mutations in BEST1. In this study we characterize the functional implications of missense bestrophin-1 mutations that cause ARB by investigating their effect on bestrophin-1's chloride conductance, cellular local...

BACKGROUND Guidelines recommend continuation or initiation of guideline-directed medical therapy, including angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEi/ARB), in hospitalized patients with heart failure with reduced ejection fraction. METHODS AND RESULTS Using the Get With The Guidelines-Heart Failure Registry, we linked clinical data from 16 052 heart failu...

The present paper is the second part of a previously published overview entitled “ten years of severe plastic deformation (SPD) in Iran”. Part I concentrates on the equal channel angular pressing (ECAP). In this part, the focus is on the accumulative roll bonding (ARB) because, currently, Iran is ranked the first in the world by the total number of publications in this field. In the present sec...

Accumulative roll bonding (ARB) was used to fabricate the Cu-Zn multilayer and Cu-Zn solid solution. A lamellar structure with the hardness of about 130 VHN was formed after eight ARB cycles. Following to the suitable heat treatment, a solid solution with a uniform microstructure and hardness of about 57 VHN was produced. The dominant wear mechanism in the ARB processed multilayer was found to ...

This paper was prepared as the result of work sponsored by the California Air Resources Board (ARB) and the California Environmental Protection Agency (Cal/EPA). It does not necessarily represent the views of the California Energy Commission, ARB, Cal/EPA, their employees, or the State of California. The Energy Commission, ARB, Cal/EPA, the State of California, their employees, contractors, and...

BACKGROUND Step therapy for angiotensin receptor blockers (ARBs) requiring prior use of angiotensin-converting enzyme inhibitors (ACEIs) is a common cost-containment intervention in managed care. OBJECTIVE This study was designed to assess the effectiveness of the step-therapy intervention for ARBs, including ARB/hydrochlorthiazide (HCTZ) combinations, as measured by prescription use patterns...

BACKGROUND/AIMS Whether angiotensin converting enzyme inhibitors (ACE) and angiotensin receptor blockers (ARB) are differentially associated with reductions in cardiovascular events and mortality in patients receiving maintenance dialysis is uncertain. We compared outcomes between ACE and ARB users among hypertensive, maintenance dialysis patients. METHODS National retrospective cohort study ...