در دهه‌های اخیر چیدمان هندسی و عناصر ریخت‌شناسی شهرها به مثابۀ عوامل مؤثر بر شکل‌گیری شدت بخشیدن پدیدۀ جزیرۀ حرارتی بیش‌ازپیش شناخته پژوهش‌هایی خصوص یافتن تأثیرات شاخص‌های معرف این موضوعات مقیاس‌های فضایی مختلف پدیده انجام شده است، هرچند تأثیر مکانی‌ـ زمانی شاخص‌ها نیز مدلی برای تفسیر طبقه‌بندی آن‌ها تنها سالیان موضوع برخی از مطالعات بوده است. متأسفانه زمینۀ طرح‌شده شهرهای بزرگ مهم کشور کماکان ...

هدف: تطبیق‌پذیری شغلی یک ویژگی مطلوب است و افرادی که انطباق بیشتری با شغل خود دارند، از رضایت داشته، روحیه‌ی مثبتی در کار نشان داده نسبت به سازمان همکاران تعهد بالایی ابراز می­کنند. هدف پژوهش حاضر واکاوی نقش میانجیگری رفتار نوآورانه تطبیق­پذیری رابطۀ بین قابلیت­های زیرساختی عجین شدن عملکرد است.طراحی/ روش‌شناسی/ رویکرد: اﻳﻦ ﭘﮋوﻫﺶ نظر ﻫﺪف ﻛﺎرﺑﺮدی ﻧﻈﺮ جمع‌آوری داده‌ها، ﭘﻴﻤﺎﻳﺸﻲ­- ﺗﻮﺻﻴﻔﻲ اﺳﺖ. جامعۀ ...

The primary recognized health risk from common deficiencies in glucose-6-phosphate dehydrogenase (G6PD), a cytoprotective enzyme for oxidative stress, is red blood cell hemolysis. Here we show that litters from untreated pregnant mutant mice with a hereditary G6PD deficiency had increased prenatal (fetal resorptions) and postnatal death. When treated with the anticonvulsant drug phenytoin, a hu...

BACKGROUND This study aimed to evaluate the prevalence and alteration of hematological parameters in malaria patients with a glucose-6-phosphate dehydrogenase (G6PD) deficiency, in the western region of Thailand, an endemic region for malaria. METHODS Data about patients with malaria hospitalized between 2013 and 2015 were collected. Clinical and sociodemographic characteristics such as age a...

The primary metabolic defect in subjects susceptible to hemolysis by various drugs and fava beans is considered to be the low glucose-6-phosphate dehydrogenase (G6PD) activity in their red cells (1, 2). Such diminished enzymatic activity could be the end result of qualitative or quantitative changes in the enzyme as well as enzyme inhibition or lack of enzyme activation. However, studies on the...

Accurate diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is required to avoid the risk of acute hemolysis associated with 8-aminoquinoline treatment. The performance of the BinaxNOW G6PD test compared with the quantitative spectrophotometric analysis of G6PD activity was assessed in 356 Plasmodium vivax-infected subjects in Brazil, Peru, Thailand, and India. In the quantitative...

Expression of the two X-linked loci glucose-6-phosphate dehydrogenase (G6PD; EC 1.1.1.49) and hypoxanthine:guanine phosphoribosyltransferase (HGPRT; EC 2.4.2.8) was studied in single hair follicles of two females who were heterozygous for both of these genes (double heterozygotes). The coupling phase for these two loci was known to be g6pd A and hyprt(-) on the maternal X chromosome and g6pd B ...

Although various tissue macrophages possess high glucose-6-phosphate dehydrogenase (G6PD) activity, which is reported to be closely associated with their phagocytotic/bactericidal function, the fine subcellular localization of this enzyme in liver resident macrophages (Kupffer cells) has not been determined. We have investigated the subcellular localization of G6PD in Kupffer cells in rat liver...

Glucose-6-phosphate dehydrogenase (G6PD) provides the reducing agent NADPH to meet the cellular needs for reductive biosynthesis and the maintenance of redox homeostasis. G6PD-deficient cells experience a high level of oxidative stress and an increased susceptibility to viral infections. Cyclooxygenase-2 (COX-2) is a key mediator in the regulation of viral replication and inflammatory response....

PURPOSE This study aimed to determine the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among infants with neonatal indirect hyperbilirubinemia (NIH); compare G6PD-deficient and G6PD-normal patients regarding hyperbilirubinemia and need for exchange transfusions (ET); and assess risk factors for ET and kernicterus. METHODS This is a case-control retrospective study. Medica...