Interferon-free direct-acting antiviral (DAA) therapies in the chronic hepatitis C virus (HCV) infections have low side effects. Sofosbuvir / ribavirin (SOF RBV) therapy combination is among currently approved treatment regimens. Aleopecia areata a very rarely comlication of this treatment. A case alopecia developed after SOF RBV patient with infection presented.

Until HCV NS3/4A protease inhibitors become available at the end of 2011, the combination pegylated-interferon (PEG-IFN)-alfa and ribavirin (RBV) will remain the standard treatment for chronic hepatitis C patients. In some hepatitis C virus-infected patients, PEG-IFN plus RBV treatment against HCV should continue to be used because of side effects of new drugs such as anemia. Our Japanese exper...

The challenge of mobilizing knowledge to improve patient care, population health and ensure effective use of resources is an enduring one in healthcare systems across the world. This commentary reflects on an earlier paper by Ferlie and colleagues that proposes the resource-based view (RBV) of the firm as a useful theoretical lens through which to study knowledge mobilization in healthcare. Spe...

In recent years strategic management scholars have expressed enormous interest in the resource-based view (RBV) of the firm. Despite its appeal as a conceptual framework, the RBV has often been criticized for lack of an empirical base. Few researchers have been able to develop measures of resources and capabilities, identify their importance in a specific industry context, and link firms’ resou...

Mixed cryoglobulinemia (MC), the most common extrahepatic manifestation of HCV, may lead to renal involvement ranging from mild urinary abnormalities to nephritic syndrome, eventually evolving to renal failure requiring renal replacement therapy. HCV eradication with pegylated interferon (PEG-IFN) and ribavirin (RBV) is the only curative treatment for MC-related membranoproliferative glomerulon...

Chronic hepatitis C virus (HCV) infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Combination therapy of pegylated interferon-alpha (PEG-IFN-α) and ribavirin (RBV) is a current standard treatment for chronic HCV infection in Korea, which has considerable adverse effects. Acute pancreatitis is a rare complication of PEG-IFN-α administration. We report a case of a 62-yea...

1041 HCV Multicentric US trials using FibroTest to diagnose cirrhosis in HCV Twelve weeks of sofosbuvir plus ribavirin is effective for treatment of genotype 2 HCV in difficult to treat u.s. veterans with cirrhosis – Results of the VALORHCV study. Samuel B. Ho1, Monto A, et al. FibroTest is used to identify cirrhotic in an open-label study to evaluate the safety and efficacy of 12 weeks of SOF+...

aminotransferases (AT) (4to 19-fold normal) known last 6 months. She had positive HCV-RNA by RT-PCR an untypable genotype. Liver biopsy revealed chronic active hepatitis grade 2, stage 2. She also had Hashimoto s thyroiditis with high titres of antithyroid antibodies. After 12 weeks of treatment with Intron A 3MU TIW and RBV 1000 mg/d, HCV RNA was negative and AT fluctuated between normal and 2...

BACKGROUND Eradication of hepatitis C virus (HCV) using direct-acting agents (DAA) has been associated with a financial burden to health authorities worldwide. We aimed to evaluate the guideline-based treatment costs by DAAs from the perspective of the Brazilian Ministry of Health (BMoH). METHODS The activity based costing method was used to estimate the cost for monitoring/treatment of genot...

Three chick assays were conducted to determine a bioavailable Zn requirement and to establish a Zn relative bioavailability (RBV) value for tetrabasic Zn chloride [TBZC, i.e., Zn5Cl2(OH)8]. In Assay 1, 8-d-old chicks were fed a Zn-deficient soy concentrate diet (8.8 mg/kg bioavailable Zn) supplemented with 0, 5.81, 10.81, 15.10, and 20.25 mg Zn/kg from ZnSO4.7H2O for 14 d to establish a linear ...