BACKGROUND Inhibition of the epidermal growth factor receptor (EGFR) has shown clinical success in patients with advanced non-small cell lung cancer (NSCLC). Somatic mutations of EGFR were found in lung adenocarcinoma that lead to exquisite dependency on EGFR signaling; thus patients with EGFR-mutant tumors are at high chance of response to EGFR inhibitors. However, imaging approaches affording...

Several new tracers are being developed for use with PET to assess pathways that are altered in cancers, including energy use, cellular signaling, transport, and proliferation. Because increased proliferation is a hallmark of many cancers, several tracers have been tested to track the DNA synthesis pathway. Thymidine, which is incorporated into DNA but not RNA, has been used in laboratory studi...

We investigated whether uptake of the thymidine analogue 3-deoxy-3-[(18)F]fluorothymidine ([(18)F]FLT) reflects proliferation in solitary pulmonary nodules (SPNs). Thirty patients with SPNs were prospectively examined with positron emission tomography. Standardized uptake values were calculated for quantification of FLT uptake. Histopathology revealed 22 malignant and 8 benign lesions. Prolifer...

Cassava (Manihot esculenta Crantz) is mainly cultivated in marginal land the south of China where seasonal drought stress occurs frequently and soil becomes more compact year by year. The study aimed to explore effect Fenlong tillage (FLT) combined with nitrogen applications on cassava rhizosphere particle composition fungal community diversity. Conventional (CT) was set as control. results ind...

PURPOSE It is often difficult to discriminate focal lymphocytic thyroiditis (FLT) or adenomatous hyperplasia (AH) from thyroid cancer if they both have suspicious ultrasound (US) findings. We aimed to make a predictive model of FLT from papillary thyroid cancer (PTC) in suspicious nodules with benign cytologic results. MATERIALS AND METHODS We evaluated 214 patients who had undergone fine-nee...

Fig 3. An example of a coregistered ADC map and [F]FLT image from the center slice of a tumor (T), which both demonstrate distinct regions of heterogeneity. These preliminary coregistration studies suggest that there may be an inverse correlation between [F]FLT uptake and ADC values, particularly in highly heterogeneous tumor regions. Ongoing work is aimed at unraveling and quantifying this rel...

Fermat's Last Theorem—which we shall abbreviate to FLT—is the (as yet unproved) assertion that the Diophantine equation x" + y" — z" has no solutions in positive integers if 11 ^ 3. It would suffice to deal with the case in which n is prime, and this is where the most significant work has been done. None the less it is not yet known even whether FLT is true for infinitely many prime exponents. ...

Abstract Background Metastasis-associated in colon cancer 1 (MACC1) and Spondin2 (SPON2) are newly discovered oncogenes, but little is known about their role colorectal cancer(CRC) liver metastases. PET has become an important molecular imaging technology due to its high sensitivity quantifiability. In particular, targeted, specific probes can detect biological behaviors. This study was designe...