The terminology and notation used in this paper are introduced in the following papers: [12], [15], [4], [10], [1], [2], [3], [9], [7], [8], [14], [11], [13], [6], and [5]. For simplicity we follow the rules: a, b, c will be real numbers, m, n will be natural numbers, k, l, i will be integers, p, q will be rational numbers, and s1, s2 will be sequences of real numbers. The following proposition...

Up to 3% of young children develop milk allergy and this may influence the development of immune-mediated diseases in later life. One protein that has been associated with allergic reactions to ruminant milk is α(S1)-casein (CN). Studies suggest that goat milk with low levels of α(S1)-CN may reduce allergenicity of milk, but the dose response to α(S1)-CN has not been confirmed. In this study, w...

The procoagulant properties of cultured vascular endothelial cells are enhanced in response to inflammatory cytokines such as tumor necrosis factor-a (TNF). A major component of this response is a reduction in expression of thrombomodulin, a cell surface cofactor for the activation of protein C. Regulation of thrombomodulin expression by TNF has been reported to occur through multiple mechanism...

For simplicity, we use the following convention: Y is a non empty set, P1, P2 are partitions of Y , A, B are subsets of Y , i is a natural number, x, y, x1, x2, z0 are sets, and X, V , d, t, S1, S2 are sets. The following proposition is true (1) If X ∈ P1 and V ∈ P1 and X ⊆ V, then X = V. Let us consider S1, S2. We introduce S1 ⋐ S2 and S2 ⋑ S1 as synonyms of S1 is finer than S2. We now state s...

We have determined the equilibrium constants for the binding of AEDANS-labelled S1 to S1-depleted 30S and 70S ribosomes. For "tight" ribosomes, the association of S1 increases with the sixth power of Mg2+ concentration, but for 30S subunits and "loose" ribosomes, there is virtually no dependence of the association on Mg2+ over the same concentration range, 2-10 mM in Mg2+. The binding of S1 to ...

Rat and human ribosomal RNA gene fragments in supercoiled plasmids were examined for S1 nuclease hypersensitivity. In the transcribed portion of genes the number and distribution of S1 sites were found to be species specific. No S1 sites were detected in the promoter regions. In the nontranscribed spacer (NTS), downstream of the 3' end of 28S RNA gene, S1 sites appear to be conserved in rat and...

To better characterize the conformational differences of G- and F-actin, we have compared the interaction between G- and F-actin with myosin subfragment 1 (S1) which had part of its F-actin binding site (residues 633-642) blocked by a complementary peptide or "antipeptide" (Chaussepied, P., and Morales, M. F. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 7471-7475). Light scattering, sedimentation, ...

We evaluated the effects of s1-receptor inhibition on m-opioid– induced mechanical antinociception and constipation. s1-Knockout mice exhibited marked mechanical antinociception in response to several m-opioid analgesics (fentanyl, oxycodone, morphine, buprenorphine, and tramadol) at systemic (subcutaneous) doses that were inactive in wild-type mice and even unmasked the antinociceptive effects...