Radiotherapy (RT) and immunotherapy (IO) may have synergistic anti-tumor effect for treating metastatic non-small-cell lung cancer (mNSCLC). However, the optimal timing of RT in relevance to IO whether it affects outcomes is unknown. We conducted a retrospective study all patients with mNSCLC treated at our institution (2011–2022). Patients who received targeted therapy or prior concurrent chem...

In obstruent consonants, a major constriction in the upper vocal tract yields an increase in intraoral pressure (P(io)). Phonation requires that subglottal pressure (P(sub)) exceed P(io) by a threshold value, so as the transglottal pressure reaches the threshold, phonation will cease. This work investigates how P(io) levels at phonation offset and onset vary before and after different German vo...

OBJECTIVE Intestinal obstruction (IO) is a disease which generates approximately 20% of emergency surgery and tends to with high mortality. Prevention of oxidative stress, bacterial translocation and tissue damage caused by IO is an important medical issue. Caffeic acid phenethyl ester (CAPE) is an anti-inflammatory, antioxidant, anti-bacterial and immunomodulatory agent. In this experimental s...

I evaluate two competing theories for microfoundations of aggregate fluctuations. The network hypothesis suggests industry-level shocks propagate across the inputoutput (IO) network of the economy, resulting in aggregate fluctuations. The granular hypothesis suggests idiosyncratic shocks to very large firms result in aggregate fluctuations. My main contribution is to connect the two aggregate f...

Idiopathic osteosclerosis (IO) is described as a localized no expansible radiopacity with unknown etiology. The IO is generally asymptomatic and could appear as round, elliptical or irregular in shape. The internal aspect is usually uniformly radiopaque. IO should be distinguished from condensing osteitis of dental origin, or other alveolar bone related radiopacities such as periapical cemental...

OBJECTIVE To investigate the effects of infant orthopedics (IO) administered in the first year of life on the speech characteristics of 2.5-year-old children with complete unilateral cleft lip and palate (UCLP) using a perceptual evaluation instrument with equal-appearing interval (EAI) scales. DESIGN In a prospective randomized clinical trial (Dutchcleft), two groups of children with complet...

INTRODUCTION Intraosseous infusion is recommended if peripheral venous access fails for cardiopulmonary resuscitation or other medical emergencies. The aim of this study, using body donors, was to compare a semi-automatic (EZ-IO®) device at two insertion sites and a sternal intraosseous infusion device (FASTR™). METHODS Twenty-seven medical students being inexperienced first-time users were r...

We construct a general-purpose indistinguishability obfuscation (IO) scheme for all polynomialsize circuits from constant-degree graded encoding schemes in the plain model, assuming the existence of a subexponentially secure Pseudo-Random Generator (PRG) computable by constantdegree arithmetic circuits (or equivalently in NC), and the subexponential hardness of the Learning With Errors (LWE) pr...