Background and Purpose N-acetylaspartate (NAA), the second most abundant amino acid derivative in the mammalian brain, is almost exclusive to neurons and their processes and, therefore, is regarded, as a marker for their health and density. Due to its unique specificity, NAA is the most frequently examined neuro-metabolite and its concentration has been reported to decline in all other central ...

The 223Ra, 224Ra, and 225Ra radioisotopes exhibit very attractive nuclear properties for application in radionuclide therapy. Unfortunately the lack of appropriate bifunctional ligand for radium is the reason why these radionuclides have not found application in receptor-targeted therapy. In the present work, the potential usefulness of the NaA nanozeolite as a carrier for radium radionuclides ...

Lower levels of N-acetylaspartate (NAA), a marker of axonal damage, have been found in the normal-appearing white matter (NAWM) of relapsing-remitting multiple sclerosis (RRMS) patients with low physical disability. However, its relation to the clinical status of these patients remains unclear. We explored the association between NAA levels [normalized to creatine (Cr), NAA/Cr] and a cognitive ...

Recent studies have provided evidence for neuronal and oligodendrocyte-related abnormalities being associated with schizophrenia. However, the functional interplay and causal relationship between these two abnormalities is poorly understood. In this report, we provide data that identify myelin and fatty-acid biosynthesis dysfunction in schizophrenia based on post-mortem brain studies (prefronta...

Zeolites are crystalline microporous materials with well-defined and uniform pore structure that find extensive industrial uses as adsorbents, catalysts and ion exchangers [1-2]. Zeolite films supported on different materials have been successfully prepared and have potential applications as highly selective membrane separators, membrane reactors, chemical sensor and microdevices [3-10]. Most o...

Luffa cylindrica belongs to the family cucurbitaceae is an economically important plant widely grown for its vegetable purpose,but the plant as a whole is able to cure many of the skin diseases,thus possess medicinal importance also. In the present study callus multiplication of the luffa from the leaf explant have been investigated with different concentrations of auxin (NAA) with cytokinine (...

Chrysanthemum nodal explants were cultured on 1⁄2 X MS medium containing different combinations of growth hormones. A reasonable callus formed on explants when MS contained 0.5 mg. cm each of BAP and NAA after about 3 weeks. Similar results were obtained on MS + 0.5 mg. cm BAP + 0.1 mg. cm NAA or 1.0 mg. cm BAP + 0.1 mg. cm NAA. A maroonish embryogenic callus was formed on MS containing BAP onl...

Canavan disease (CD) is an autosomal recessive disorder, characterized by spongy degeneration of the brain. Patients with CD have aspartoacylase (ASPA) deficiency, which results accumulation of N-acetylaspartic acid (NAA) in the brain and elevated excretion of urinary NAA. Clinically, patients with CD have macrocephaly, mental retardation and hypotonia. A knockout mouse for CD which was enginee...

The growing demand for rapid diagnosis of tuberculosis (TB) has led to the incorporation of nucleic acid amplification (NAA) tests in case definitions. The objective of this study was to evaluate the contribution of a real-time polymerase chain reaction (PCR) assay in providing a result predictive of a confirmed TB case. Respiratory and extra-pulmonary specimens (n = 308) were subjected to NAA...