UNLABELLED Management of the complex chronic disease of early childhood caries requires a system of coordinated health care interventions which can be led by a dental hygienist and where patient self-care efforts are paramount. BACKGROUND AND PURPOSE Even after receiving costly surgical treatment under general anesthesia in the operating room, many children develop new and recurrent caries af...

PURPOSE To examine the effects of glia-derived and brain-derived neurotrophic factors on survival and morphology of cultured retinal ganglion cells (RGCs) from adult porcine retina. METHODS Adult porcine retinas were dissociated and cultured in different conditions: (1) on laminin- and poly-D-lysine-coated coverslips in chemically defined medium (CDM); (2) on laminin- and poly-D-lysine-coated...

BACKGROUND Pulmonary rehabilitation (PR) is recommended after a severe COPD exacerbation, but its short- and long-term effects on health care utilization have not been fully established. AIMS The aims of this study were to evaluate patient compliance with a chronic disease management (CDM) program incorporating home-based exercise training as the main component after a severe COPD exacerbatio...

OBJECTIVE Systematic analysis of observational medical databases for active safety surveillance is hindered by the variation in data models and coding systems. Data analysts often find robust clinical data models difficult to understand and ill suited to support their analytic approaches. Further, some models do not facilitate the computations required for systematic analysis across many interv...

Epstein-Barr virus (EBV) has widely infected more than 90% of human populations. Currently, there is no efficient way to remove the virus because the EBV carriers are usually in a latent stage that allows them to escape the immune system and common antiviral drugs. In the effort to develop an efficient strategy for the removal of the EBV virus, we have shown that betulinic acid (BA) slightly su...

N -body simulations predict that CDM halo-assembly occurs in two phases: 1) a rapid accretion phase dominated by major mergers with a rapidly deepening potential well; and 2) a slow accretion phase characterised by a gentle addition of mass to the outer halo with little change in the inner potential well. We demonstrate, using onedimensional simulations, that this two-phase accretion leads to C...

COBE-normalized flat (matter plus cosmological constant) and open Cold Dark Matter (CDM) models are tested by comparing their expected Hubble flow variations and the observed variations in a Type Ia supernova sample and a Tully Fisher cluster sample. The test provides a probe of the CDM power spectrum on scales of 0.02h Mpc < ∼ k < ∼ 0.2h Mpc, free of the bias factor b. The results favor a low ...

Shock waves driven in the intergalactic medium during the merging of galaxy clusters have been observed in X-ray imaging and spectroscopy. Fluid motions inferred from the shock strength and morphology can be compared to the cold dark matter (CDM) distribution inferred from gravitational lensing. A detailed reconstruction of the CDM kinematics, however, must take into account the nontrivial resp...

Shock waves driven in the intergalactic medium during the merging of galaxy clusters have been observed in X-ray imaging and spectroscopy. Fluid motions inferred from the shock strength and morphology can be compared to the cold dark matter (CDM) distribution inferred from gravitational lensing. A detailed reconstruction of the CDM kinematics, however, must take into account the nontrivial resp...

OBJECTIVES To evaluate the utility of applying the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) across multiple observational databases within an organization and to apply standardized analytics tools for conducting observational research. MATERIALS AND METHODS Six deidentified patient-level datasets were transformed to the OMOP CDM. We evaluated the extent of inf...